Cause-specific Cox regression model of risk factors for SCNSL with death without SCNSL and non-CNS relapse as competing events
| Risk factors . | Univariate (HR [95% CI]) . | Multivariate (HR [95% CI])∗ . |
|---|---|---|
| Age >60 | 1.5 (0.8-2.6) | 1.4 (0.7-2.6) |
| PS 2-4 | 4.6 (2.8-7.6) | 2.5 (1.4-4.3) |
| Ann Arbor stage III-IV | 2.7 (1.5-5.0) | 1.0 (0.5-2.1) |
| EN sites | ||
| 1 | 4.3 (1.8- 10.5) | 3.5 (1.4-8.6) |
| 2 | 7.15 (2.8-18.2) | 5.1 (1.9-13.7) |
| >2 | 10.8 (4.4-26.9) | 7.0 (2.6-18.5) |
| LDH, elevated | 3.1 (1.8-5.3) | 2.1 (1.5-3.7) |
| B symptoms, present | 2.42 (1.5-4.0) | 1.3 (0.8-2.3) |
| EN sites | Univariate (HR [95% CI]) | Multivariate (HR [95% CI])† |
| Orbits | 1.7 (0.2-12.5) | 2.7 (0.4-20.0) |
| Nasal cavity | 0.9 (0.1-6.5) | 0.5 (0.1-3.7) |
| Oral cavity | 2.0 (0.6-6.3) | 2.8 (0.9-9.2) |
| Salivary glands | 1.0 (0.1-7.1) | 1.5 (0.2-11.3) |
| Thyroid gland | 2.2 (0.8-6.1) | 2.0 (0.7-5.6) |
| Heart | 4.9 (1.5-15.6) | 3.7 (1.2-12.0) |
| Lungs | 1.5 (0.8-3.0) | 1.1 (0.5-2.1) |
| Stomach | 1.7 (0.8-3.8) | 1.5 (0.7-3.3) |
| Small intestine | 1.7 (0.7-4.0) | 1.7 (0.7-3.9) |
| Large intestine | 1.6 (0.7-3.8) | 1.3 (0.6-3.1) |
| Pancreas | 1.9 (0.7-5.2) | 1.3 (0.5-3.7) |
| Kidney/adrenal glands | 5.4 (3.0-9.4) | 3.7 (2.0-6.8) |
| Liver | 1.1 (0.5-2.5) | 0.6 (0.2-1.4) |
| Ascites | 2.2 (0.3-16.0) | 1.0 (0.1-6.9) |
| Bladder | 3.0 (0.4-22.0) | 2.3 (0.3-17.0) |
| Skin | 2.2 (1.0-4.6) | 2.0 (0.9-4.4) |
| Muscle | 1.0 (0.4-2.4) | 0.8 (0.3-1.9) |
| Bone | 1.3 (0.74-2.4) | 0.9 (0.5-1.7) |
| Bone marrow | 4.0 (2.4-6.5) | 3.2 (1.9-5.5) |
| Breast | 4.4 (1.3-15.0) | 2.8 (0.6-12.5) |
| Ovaries | 18.0 (6.0-53.9) | 19.0 (5.8-60.8) |
| Uterus | 13.2 (4.4-39.4) | 11.4 (3.5-36.8) |
| Testes | 4.0 (1.9-8.5) | 5.8 (2.7-12.7) |
| Risk factors . | Univariate (HR [95% CI]) . | Multivariate (HR [95% CI])∗ . |
|---|---|---|
| Age >60 | 1.5 (0.8-2.6) | 1.4 (0.7-2.6) |
| PS 2-4 | 4.6 (2.8-7.6) | 2.5 (1.4-4.3) |
| Ann Arbor stage III-IV | 2.7 (1.5-5.0) | 1.0 (0.5-2.1) |
| EN sites | ||
| 1 | 4.3 (1.8- 10.5) | 3.5 (1.4-8.6) |
| 2 | 7.15 (2.8-18.2) | 5.1 (1.9-13.7) |
| >2 | 10.8 (4.4-26.9) | 7.0 (2.6-18.5) |
| LDH, elevated | 3.1 (1.8-5.3) | 2.1 (1.5-3.7) |
| B symptoms, present | 2.42 (1.5-4.0) | 1.3 (0.8-2.3) |
| EN sites | Univariate (HR [95% CI]) | Multivariate (HR [95% CI])† |
| Orbits | 1.7 (0.2-12.5) | 2.7 (0.4-20.0) |
| Nasal cavity | 0.9 (0.1-6.5) | 0.5 (0.1-3.7) |
| Oral cavity | 2.0 (0.6-6.3) | 2.8 (0.9-9.2) |
| Salivary glands | 1.0 (0.1-7.1) | 1.5 (0.2-11.3) |
| Thyroid gland | 2.2 (0.8-6.1) | 2.0 (0.7-5.6) |
| Heart | 4.9 (1.5-15.6) | 3.7 (1.2-12.0) |
| Lungs | 1.5 (0.8-3.0) | 1.1 (0.5-2.1) |
| Stomach | 1.7 (0.8-3.8) | 1.5 (0.7-3.3) |
| Small intestine | 1.7 (0.7-4.0) | 1.7 (0.7-3.9) |
| Large intestine | 1.6 (0.7-3.8) | 1.3 (0.6-3.1) |
| Pancreas | 1.9 (0.7-5.2) | 1.3 (0.5-3.7) |
| Kidney/adrenal glands | 5.4 (3.0-9.4) | 3.7 (2.0-6.8) |
| Liver | 1.1 (0.5-2.5) | 0.6 (0.2-1.4) |
| Ascites | 2.2 (0.3-16.0) | 1.0 (0.1-6.9) |
| Bladder | 3.0 (0.4-22.0) | 2.3 (0.3-17.0) |
| Skin | 2.2 (1.0-4.6) | 2.0 (0.9-4.4) |
| Muscle | 1.0 (0.4-2.4) | 0.8 (0.3-1.9) |
| Bone | 1.3 (0.74-2.4) | 0.9 (0.5-1.7) |
| Bone marrow | 4.0 (2.4-6.5) | 3.2 (1.9-5.5) |
| Breast | 4.4 (1.3-15.0) | 2.8 (0.6-12.5) |
| Ovaries | 18.0 (6.0-53.9) | 19.0 (5.8-60.8) |
| Uterus | 13.2 (4.4-39.4) | 11.4 (3.5-36.8) |
| Testes | 4.0 (1.9-8.5) | 5.8 (2.7-12.7) |