CFB to week 48 in Hb, hemolytic markers, and QoL in patients with wAIHA
| Parameter . | Baseline . | Week 48 . | % CFB to week 48 . | CFB to week 48 . |
|---|---|---|---|---|
| Hb, g/dL | n = 11 | n = 7 | n = 7 | n = 7 |
| Median (IQR) | 9.0 (8.00-10.10) | 10.6 (9.10-11.00) | 18.9 (−13.33 to 32.22) | 1.7 (−1.40 to 2.90) |
| Mean (SD) | 8.8 (1.67) | 10.3 (1.11) | 13.0 (21.05) | 1.0 (1.92) |
| Hemolytic markers | ||||
| LDH, IU/L | n = 11 | n = 7 | n = 7 | n = 7 |
| Median (IQR) | 263.0 (173.0-531.0) | 134.0 (121.0-149.0) | −36.0 (−51.1 to 2.1) | −68.0 (−137.0 to 3.0) |
| Mean (SD) | 544.5 (820.05) | 142.1 (27.58) | −30.7 (30.40) | −102.3 (140.87) |
| Indirect bilirubin, μmol/L | n = 11 | n = 7 | n = 7 | n = 7 |
| Median (IQR) | 15.4 (10.30-20.52) | 1.7 (0.00-5.13) | −81.81 (−100.00 to −62.55) | −10.26 (−15.38 to −5.26) |
| Mean (SD) | 25.7 (27.72) | 2.7 (2.60) | −81.3 (16.12) | −10.3 (4.28) |
| ARC, ×109/L | n = 11 | n = 7 | n = 7 | n = 7 |
| Median (IQR) | 228.2 (106.86-255.00) | 58.0 (42.00-75.00) | −69.8 (−81.20 to −45.72) | −168.7 (−181.44 to −48.86) |
| Mean (SD) | 226.4 (137.41) | 65.5 (36.82) | −64.0 (18.90) | −138.7 (76.20) |
| Haptoglobin, g/L | n = 11 | n = 7 | n = 7 | n = 7 |
| Median (IQR) | 0.1 (0.10-0.42) | 0.9 (0.61-1.56) | 510.0 (5.41-1292.86) | 0.5 (0.04-1.46) |
| Mean (SD) | 0.3 (0.28) | 1.0 (0.63) | 586.6 (614.55) | 0.7 (0.68) |
| QoL end points | ||||
| FACIT-fatigue scale, score | n = 11 | n = 7 | n = 7 | n = 7 |
| Median (IQR) | 32.0 (16.0-45.0) | 35.0 (34.0-48.0) | 11.1 (−23.9 to 45.8) | 4.0 (−11.0 to 11.0) |
| Mean (SD) | 31.5 (14.42) | 38.6 (7.25) | 18.3 (43.32) | 2.4 (10.23) |
| LASA, score | n = 11 | n = 7 | n = 7 | n = 7 |
| Median (IQR) | 6.0 (4.00-9.00) | 8.0 (6.00-8.00) | 28.6 (−30.00 to 33.33) | 2.0 (−3.00 to 2.00) |
| Mean (SD) | 6.0 (2.72) | 7.4 (1.13) | 74.4 (189.92) | 0.6 (2.99) |
| Parameter . | Baseline . | Week 48 . | % CFB to week 48 . | CFB to week 48 . |
|---|---|---|---|---|
| Hb, g/dL | n = 11 | n = 7 | n = 7 | n = 7 |
| Median (IQR) | 9.0 (8.00-10.10) | 10.6 (9.10-11.00) | 18.9 (−13.33 to 32.22) | 1.7 (−1.40 to 2.90) |
| Mean (SD) | 8.8 (1.67) | 10.3 (1.11) | 13.0 (21.05) | 1.0 (1.92) |
| Hemolytic markers | ||||
| LDH, IU/L | n = 11 | n = 7 | n = 7 | n = 7 |
| Median (IQR) | 263.0 (173.0-531.0) | 134.0 (121.0-149.0) | −36.0 (−51.1 to 2.1) | −68.0 (−137.0 to 3.0) |
| Mean (SD) | 544.5 (820.05) | 142.1 (27.58) | −30.7 (30.40) | −102.3 (140.87) |
| Indirect bilirubin, μmol/L | n = 11 | n = 7 | n = 7 | n = 7 |
| Median (IQR) | 15.4 (10.30-20.52) | 1.7 (0.00-5.13) | −81.81 (−100.00 to −62.55) | −10.26 (−15.38 to −5.26) |
| Mean (SD) | 25.7 (27.72) | 2.7 (2.60) | −81.3 (16.12) | −10.3 (4.28) |
| ARC, ×109/L | n = 11 | n = 7 | n = 7 | n = 7 |
| Median (IQR) | 228.2 (106.86-255.00) | 58.0 (42.00-75.00) | −69.8 (−81.20 to −45.72) | −168.7 (−181.44 to −48.86) |
| Mean (SD) | 226.4 (137.41) | 65.5 (36.82) | −64.0 (18.90) | −138.7 (76.20) |
| Haptoglobin, g/L | n = 11 | n = 7 | n = 7 | n = 7 |
| Median (IQR) | 0.1 (0.10-0.42) | 0.9 (0.61-1.56) | 510.0 (5.41-1292.86) | 0.5 (0.04-1.46) |
| Mean (SD) | 0.3 (0.28) | 1.0 (0.63) | 586.6 (614.55) | 0.7 (0.68) |
| QoL end points | ||||
| FACIT-fatigue scale, score | n = 11 | n = 7 | n = 7 | n = 7 |
| Median (IQR) | 32.0 (16.0-45.0) | 35.0 (34.0-48.0) | 11.1 (−23.9 to 45.8) | 4.0 (−11.0 to 11.0) |
| Mean (SD) | 31.5 (14.42) | 38.6 (7.25) | 18.3 (43.32) | 2.4 (10.23) |
| LASA, score | n = 11 | n = 7 | n = 7 | n = 7 |
| Median (IQR) | 6.0 (4.00-9.00) | 8.0 (6.00-8.00) | 28.6 (−30.00 to 33.33) | 2.0 (−3.00 to 2.00) |
| Mean (SD) | 6.0 (2.72) | 7.4 (1.13) | 74.4 (189.92) | 0.6 (2.99) |
Abbreviations are explained in Table 1.