CFB to week 48 in Hb, hemolytic markers, and QoL in patients with CAD
| Parameter . | Baseline . | Week 48 . | % CFB to week 48 . | CFB to week 48 . |
|---|---|---|---|---|
| Hb, g/dL | n = 13 | n = 10 | n = 10 | n = 10 |
| Median (IQR) | 9.2 (8.10-9.80) | 11.0 (10.10-12.30) | 26.5 (9.78-32.26) | 2.4 (0.90-3.00) |
| Mean (SD) | 8.9 (1.34) | 11.2 (1.14) | 23.5 (18.92) | 2.0 (1.59) |
| Hemolytic markers | ||||
| LDH, IU/L | n = 13 | n = 10 | n = 10 | n = 10 |
| Median (IQR) | 329.0 (232.0-471.0) | 182.0 (167.0-225.0) | −21.9 (−54.3 to −8.1) | −52.0 (−184.0 to −16.0) |
| Mean (SD) | 468.2 (520.2) | 220.8 (109.6) | −29.3 (32.0) | −276.8 (601.5) |
| Indirect bilirubin, μmol/L | n = 13 | n = 10 | n = 10 | n = 10 |
| Median (IQR) | 25.7 (18.81-39.30) | 8.0 (3.42-13.68) | −71.5 (−84.59 to −36.36) | −15.4 (−25.62 to −6.89) |
| Mean (SD) | 31.7 (18.06) | 8.7 (6.26) | −62.5 (29.33) | −16.9 (11.18) |
| ARC, ×109/L | n = 12 | n = 10 | n = 9 | n = 9 |
| Median (IQR) | 148.1 (103.40-157.28) | 79.7 (50.60-95.12) | −51.7 (−67.81 to −34.97) | −94.8 (−109.60 to −51.16) |
| Mean (SD) | 138.6 (64.20) | 80.1 (40.21) | −46.7 (30.34) | −79.4 (55.69) |
| Haptoglobin, g/L | n = 13 | n = 11 | n = 11 | n = 11 |
| Median (IQR) | 0.1 (0.100-0.100) | 0.6 (0.40-0.93) | 320.0 (0.00-550.00) | 0.3 (0.00-0.55) |
| Mean (SD) | 0.2 (0.37) | 0.6 (0.38) | 389.1 (410.37) | 0.4 (0.45) |
| QoL end points | ||||
| FACIT-fatigue scale, score | n = 13 | n = 10 | n = 10 | n = 10 |
| Median (IQR) | 26.0 (21.0-36.0) | 32.5 (32.0-46.0) | 21.2 (4.6-52.4) | 6.0 (2.0-11.0) |
| Mean (SD) | 27.2 (9.93) | 33.3 (13.34) | 21.8 (48.57) | 3.9 (13.57) |
| LASA, score | n = 13 | n = 10 | n = 10 | n = 10 |
| Median (IQR) | 5.0 (4.00-7.00) | 6.5 (5.00-9.00) | 14.6 (0.00-50.00) | 1.0 (0.00-2.00) |
| Mean (SD) | 5.5 (1.85) | 6.8 (1.81) | 20.6 (30.50) | 0.9 (1.45) |
| Parameter . | Baseline . | Week 48 . | % CFB to week 48 . | CFB to week 48 . |
|---|---|---|---|---|
| Hb, g/dL | n = 13 | n = 10 | n = 10 | n = 10 |
| Median (IQR) | 9.2 (8.10-9.80) | 11.0 (10.10-12.30) | 26.5 (9.78-32.26) | 2.4 (0.90-3.00) |
| Mean (SD) | 8.9 (1.34) | 11.2 (1.14) | 23.5 (18.92) | 2.0 (1.59) |
| Hemolytic markers | ||||
| LDH, IU/L | n = 13 | n = 10 | n = 10 | n = 10 |
| Median (IQR) | 329.0 (232.0-471.0) | 182.0 (167.0-225.0) | −21.9 (−54.3 to −8.1) | −52.0 (−184.0 to −16.0) |
| Mean (SD) | 468.2 (520.2) | 220.8 (109.6) | −29.3 (32.0) | −276.8 (601.5) |
| Indirect bilirubin, μmol/L | n = 13 | n = 10 | n = 10 | n = 10 |
| Median (IQR) | 25.7 (18.81-39.30) | 8.0 (3.42-13.68) | −71.5 (−84.59 to −36.36) | −15.4 (−25.62 to −6.89) |
| Mean (SD) | 31.7 (18.06) | 8.7 (6.26) | −62.5 (29.33) | −16.9 (11.18) |
| ARC, ×109/L | n = 12 | n = 10 | n = 9 | n = 9 |
| Median (IQR) | 148.1 (103.40-157.28) | 79.7 (50.60-95.12) | −51.7 (−67.81 to −34.97) | −94.8 (−109.60 to −51.16) |
| Mean (SD) | 138.6 (64.20) | 80.1 (40.21) | −46.7 (30.34) | −79.4 (55.69) |
| Haptoglobin, g/L | n = 13 | n = 11 | n = 11 | n = 11 |
| Median (IQR) | 0.1 (0.100-0.100) | 0.6 (0.40-0.93) | 320.0 (0.00-550.00) | 0.3 (0.00-0.55) |
| Mean (SD) | 0.2 (0.37) | 0.6 (0.38) | 389.1 (410.37) | 0.4 (0.45) |
| QoL end points | ||||
| FACIT-fatigue scale, score | n = 13 | n = 10 | n = 10 | n = 10 |
| Median (IQR) | 26.0 (21.0-36.0) | 32.5 (32.0-46.0) | 21.2 (4.6-52.4) | 6.0 (2.0-11.0) |
| Mean (SD) | 27.2 (9.93) | 33.3 (13.34) | 21.8 (48.57) | 3.9 (13.57) |
| LASA, score | n = 13 | n = 10 | n = 10 | n = 10 |
| Median (IQR) | 5.0 (4.00-7.00) | 6.5 (5.00-9.00) | 14.6 (0.00-50.00) | 1.0 (0.00-2.00) |
| Mean (SD) | 5.5 (1.85) | 6.8 (1.81) | 20.6 (30.50) | 0.9 (1.45) |
Abbreviations are explained in Table 1.