Predicted response rate based on PopPK modeling and simulations
| Trough sampling time . | 25/25/50 mg/m2 MWF (6 doses) % (95% CI) . | 25 mg/m2 q48h (7 doses) % (95% CI) . | |||
|---|---|---|---|---|---|
| IM . | IV . | IV/IV/IM . | IM . | IV . | |
| 48 h | 95 (94-96) | 84 (82-86) | 90 (88-91) | 97 (96-97) | 83 (82-85) |
| 72 h | 88 (87-90) | 38 (36-40) | 89 (87-90) | N/A | N/A |
| Trough sampling time . | 25/25/50 mg/m2 MWF (6 doses) % (95% CI) . | 25 mg/m2 q48h (7 doses) % (95% CI) . | |||
|---|---|---|---|---|---|
| IM . | IV . | IV/IV/IM . | IM . | IV . | |
| 48 h | 95 (94-96) | 84 (82-86) | 90 (88-91) | 97 (96-97) | 83 (82-85) |
| 72 h | 88 (87-90) | 38 (36-40) | 89 (87-90) | N/A | N/A |
Predicted response rate is calculated from the proportion of participants achieving NSAA of ≥0.1 IU/mL. For MWF dosing regimens, data are shown for 48 hours from the last 25 mg/m2 dose and 72 hours from the last 50 mg/m2 dose. For q48h regimens, data are shown for 48 hours after the seventh dose of 25 mg/m2.
N/A, not available; q48h, every 48 hours.