Table 4.

Univariate regression analysis for prediction of infection identified (N = 248)

ParameterNo infection identified (n = 101)Infection identified (n = 147)Odds ratio95% CIP valueAUC
Disease and patient characteristics, n (%)       
Age, median (range), y 56 (22-77) 56 (21-85) 1.00 0.98-1.02 .92 0.51 
Sex, male (ref = female) 63 (47) 70 (53) 0.56 0.33-0.93 .026 0.57 
Newly diagnosed (ref = relapsed/refractory) 84 (44) 105 (56) 0.51 0.27-0.95 .04 0.56 
Secondary disease (ref = de novo) 19 (40) 29 (60) 1.0 0.56-2.02 .86 0.500 
Prior stem cell transplant 5 (26) 14 (74) 2.02 0.70-5.80 .19 0.52 
Duration of prior neutropenia (per wk) 2.16 (0.14-12.43) 1.99 (0.14-10.00) 0.95 0.83-1.10 .52 0.51 
ECOG PS 2-4 (ref = PS 0-1) 17 (39) 27 (61) 1.16 0.59-2.28 .66 0.51 
Transfusion <24 h 53 (46) 63 (54) 0.68 0.41-1.13 .14 0.55 
Comorbidities, n (%)       
COPD 4 (57) 3 (43) 0.51 0.11-2.31 .38 0.51 
Other Pulmonary disorder 22 (45) 27 (55) 0.81 0.43-1.53 .52 0.52 
Congestive heart failure 14 (41) 20 (59) 0.97 0.46-2.04 .94 0.50 
Other cardiac conditions 38 (41) 54 (59) 0.96 0.57-1.63 .89 0.50 
Diabetes 12 (34) 23 (66) 1.38 0.65-2.91 .40 0.52 
Prior fungal infection 7 (29) 17 (71) 1.76 0.70-4.40 .23 0.52 
Baseline laboratory values, median (range)       
ANC 0 (0-0.6) 0 (0-0.8) 0.86 0.07-10.75 .91 0.56 
ALC 0.12 (0-1.55) 0.06 (0-1.07) 0.09 0.01-0.59 .012 0.60 
AMC 0.17 (0-4.50) 0.08 (0-2.70) 0.69 0.39-1.22 .20 0.55 
Hematocrit 25.2 (14-43) 26.8 (16, 46) 1.02 0.97-1.06 .48 0.54 
Creatinine 0.78 (0.08-2.57) 0.79 (0.39-1.69) 1.11 0.44-2.76 .82 0.53 
Albumin 3.5 (2.8-4.3) 3.5 (2.4-4.4) 1.62 0.83-3.14 .16 0.55 
Sodium 135 (124-42) 135 (124-144) 0.98 0.92-1.06 .66 0.53 
Potassium 3.77 (2.80-4.60) 3.66 (2.60-4.50) 0.43 0.21-0.88 .021 0.57 
CO2 26 (19-33) 24 (12-31) 0.92 0.84-1.01 .096 0.55 
Anion gap 7.6 (2-12) 8.5 (4-16) 1.22 1.07-1.39 .003 0.61 
Physiologic parameters, median (range)       
Initial systolic BP 126 (78-161) 126 (65-173) 1.00 0.99-1.01 .98 0.98 
Initial MAP 91 (61-120) 91 (45-130) 1.00 0.98-1.02 .72 0.50 
Initial heart rate (per 10 BPM) 9.35 (3.93-13.4) 9.88 (3.82-15.2) 1.13 1.00-1.28 .052 0.59 
Initial respiratory rate 18 (16-25) 19 (12-36) 1.18 1.05-1.32 .004 0.59 
Initial pulse oxygenation 98 (89-100) 98 (90-100) 0.94 0.82-1.08 .39 0.52 
Lowest systolic BP 99 (39- 137) 95 (51-132) 0.98 0.96-1.00 .025 0.61 
Lowest MAP 73 (46-98) 69 (40-96) 0.97 0.94-0.99 .006 0.62 
Largest heart rate (per 10 BPM) 10.37 (7.10-16.00) 11.23 (6.60-21.30) 1.22 1.07-1.39 .003 0.60 
Highest respiratory rate 20 (16-36) 23 (16-54) 1.16 1.07-1.24 <.001 0.67 
Highest fever 38.6 (37- 40.3) 39.0 (36.7-41.0) 2.26 1.54-3.31 <.001 0.66 
Highest fever >39°C 29 (25) 86 (75) 3.40 1.98-5.86 <.001 0.65 
ParameterNo infection identified (n = 101)Infection identified (n = 147)Odds ratio95% CIP valueAUC
Disease and patient characteristics, n (%)       
Age, median (range), y 56 (22-77) 56 (21-85) 1.00 0.98-1.02 .92 0.51 
Sex, male (ref = female) 63 (47) 70 (53) 0.56 0.33-0.93 .026 0.57 
Newly diagnosed (ref = relapsed/refractory) 84 (44) 105 (56) 0.51 0.27-0.95 .04 0.56 
Secondary disease (ref = de novo) 19 (40) 29 (60) 1.0 0.56-2.02 .86 0.500 
Prior stem cell transplant 5 (26) 14 (74) 2.02 0.70-5.80 .19 0.52 
Duration of prior neutropenia (per wk) 2.16 (0.14-12.43) 1.99 (0.14-10.00) 0.95 0.83-1.10 .52 0.51 
ECOG PS 2-4 (ref = PS 0-1) 17 (39) 27 (61) 1.16 0.59-2.28 .66 0.51 
Transfusion <24 h 53 (46) 63 (54) 0.68 0.41-1.13 .14 0.55 
Comorbidities, n (%)       
COPD 4 (57) 3 (43) 0.51 0.11-2.31 .38 0.51 
Other Pulmonary disorder 22 (45) 27 (55) 0.81 0.43-1.53 .52 0.52 
Congestive heart failure 14 (41) 20 (59) 0.97 0.46-2.04 .94 0.50 
Other cardiac conditions 38 (41) 54 (59) 0.96 0.57-1.63 .89 0.50 
Diabetes 12 (34) 23 (66) 1.38 0.65-2.91 .40 0.52 
Prior fungal infection 7 (29) 17 (71) 1.76 0.70-4.40 .23 0.52 
Baseline laboratory values, median (range)       
ANC 0 (0-0.6) 0 (0-0.8) 0.86 0.07-10.75 .91 0.56 
ALC 0.12 (0-1.55) 0.06 (0-1.07) 0.09 0.01-0.59 .012 0.60 
AMC 0.17 (0-4.50) 0.08 (0-2.70) 0.69 0.39-1.22 .20 0.55 
Hematocrit 25.2 (14-43) 26.8 (16, 46) 1.02 0.97-1.06 .48 0.54 
Creatinine 0.78 (0.08-2.57) 0.79 (0.39-1.69) 1.11 0.44-2.76 .82 0.53 
Albumin 3.5 (2.8-4.3) 3.5 (2.4-4.4) 1.62 0.83-3.14 .16 0.55 
Sodium 135 (124-42) 135 (124-144) 0.98 0.92-1.06 .66 0.53 
Potassium 3.77 (2.80-4.60) 3.66 (2.60-4.50) 0.43 0.21-0.88 .021 0.57 
CO2 26 (19-33) 24 (12-31) 0.92 0.84-1.01 .096 0.55 
Anion gap 7.6 (2-12) 8.5 (4-16) 1.22 1.07-1.39 .003 0.61 
Physiologic parameters, median (range)       
Initial systolic BP 126 (78-161) 126 (65-173) 1.00 0.99-1.01 .98 0.98 
Initial MAP 91 (61-120) 91 (45-130) 1.00 0.98-1.02 .72 0.50 
Initial heart rate (per 10 BPM) 9.35 (3.93-13.4) 9.88 (3.82-15.2) 1.13 1.00-1.28 .052 0.59 
Initial respiratory rate 18 (16-25) 19 (12-36) 1.18 1.05-1.32 .004 0.59 
Initial pulse oxygenation 98 (89-100) 98 (90-100) 0.94 0.82-1.08 .39 0.52 
Lowest systolic BP 99 (39- 137) 95 (51-132) 0.98 0.96-1.00 .025 0.61 
Lowest MAP 73 (46-98) 69 (40-96) 0.97 0.94-0.99 .006 0.62 
Largest heart rate (per 10 BPM) 10.37 (7.10-16.00) 11.23 (6.60-21.30) 1.22 1.07-1.39 .003 0.60 
Highest respiratory rate 20 (16-36) 23 (16-54) 1.16 1.07-1.24 <.001 0.67 
Highest fever 38.6 (37- 40.3) 39.0 (36.7-41.0) 2.26 1.54-3.31 <.001 0.66 
Highest fever >39°C 29 (25) 86 (75) 3.40 1.98-5.86 <.001 0.65 

BPM, beats per minute.

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