Table 2. Univariate regression analysis... | American Society of Hematology

Table 2.

Univariate regression analysis for prediction of HR admission (N = 248)

Parameter	Odds ratio	95% Confidence interval (CI)	P value	AUC
Disease and patient characteristics
Age, median (range), y	0.96	0.93-0.99	.004	0.65
ND (ref = relapsed/refractory)	0.44	0.16-1.18	.1	0.56
Secondary disease (ref = de novo)	0.88	0.38-2.07	.77	0.51
Prior stem cell transplant	0.65	0.2-2.09	.47	0.52
Duration of prior neutropenia (per wk)	1.11	0.88-1.41	.38	0.54
ECOG PS 2-4 (ref = PS 0-1)	0.83	0.35-1.96	.66	0.52
Transfusion <24 h	0.97	0.49-1.94	.94	0.50
Comorbidities
COPD	0.44	0.08-2.35	.34	0.51
Other Pulmonary disorder	1.38	0.54-3.52	.50	0.52
Congestive heart failure	1.48	0.33-6.74	.61	0.51
Other cardiac	1.33	0.64-2.27	.45	0.53
Diabetes	1.47	0.49-4.44	.49	0.52
Prior fungal infection	1.3	0.37-4.48	.69	0.51
Baseline laboratory values
ANC	0.10	0.01-1.47	.09	0.58
ALC	0.26	0.05-1.35	.11	0.58
AMC	0.57	0.32-0.99	.047	0.65
Hematocrit	1.02	0.94-1.11	.62	0.52
Creatinine	1.48	0.40-5.55	.56	0.52
Albumin	0.64	0.27-1.55	.33	0.51
Sodium	0.99	0.90-1.10	.89	0.51
CO₂ (per 10 mmol/L)	1.06	0.52-2.13	.88	0.52
Lactate	1.25	0.74-2.1	.41	0.58
Anion gap	1.07	0.91-1.27	.41	0.55
Physiologic parameters
Initial systolic BP	0.99	0.97-1.01	.31	0.55
Initial MAP	1.00	0.97-1.03	.92	0.50
Initial heart rate	1.21	1.02-1.43	.027	0.63
Initial respiratory rate	1.11	0.96-1.29	.17	0.60
Initial pulse oxygenation	1.12	0.94-1.33	.20	0.58
Lowest systolic BP	0.97	0.95-1.00	.04	0.60
Lowest MAP	0.97	0.94-1.00	.08	0.58
Largest heart rate (per 10 BPM)	1.7	1.34-2.16	<.001	0.74
Highest respiratory rate	1.1	1.00-1.22	.05	0.62
Highest fever	3.66	2.11-6.33	<.001	0.76
Highest fever >39°C	13.09	3.9-43.94	<.001	0.73

Parameter	Odds ratio	95% Confidence interval (CI)	P value	AUC
Disease and patient characteristics
Age, median (range), y	0.96	0.93-0.99	.004	0.65
ND (ref = relapsed/refractory)	0.44	0.16-1.18	.1	0.56
Secondary disease (ref = de novo)	0.88	0.38-2.07	.77	0.51
Prior stem cell transplant	0.65	0.2-2.09	.47	0.52
Duration of prior neutropenia (per wk)	1.11	0.88-1.41	.38	0.54
ECOG PS 2-4 (ref = PS 0-1)	0.83	0.35-1.96	.66	0.52
Transfusion <24 h	0.97	0.49-1.94	.94	0.50
Comorbidities
COPD	0.44	0.08-2.35	.34	0.51
Other Pulmonary disorder	1.38	0.54-3.52	.50	0.52
Congestive heart failure	1.48	0.33-6.74	.61	0.51
Other cardiac	1.33	0.64-2.27	.45	0.53
Diabetes	1.47	0.49-4.44	.49	0.52
Prior fungal infection	1.3	0.37-4.48	.69	0.51
Baseline laboratory values
ANC	0.10	0.01-1.47	.09	0.58
ALC	0.26	0.05-1.35	.11	0.58
AMC	0.57	0.32-0.99	.047	0.65
Hematocrit	1.02	0.94-1.11	.62	0.52
Creatinine	1.48	0.40-5.55	.56	0.52
Albumin	0.64	0.27-1.55	.33	0.51
Sodium	0.99	0.90-1.10	.89	0.51
CO₂ (per 10 mmol/L)	1.06	0.52-2.13	.88	0.52
Lactate	1.25	0.74-2.1	.41	0.58
Anion gap	1.07	0.91-1.27	.41	0.55
Physiologic parameters
Initial systolic BP	0.99	0.97-1.01	.31	0.55
Initial MAP	1.00	0.97-1.03	.92	0.50
Initial heart rate	1.21	1.02-1.43	.027	0.63
Initial respiratory rate	1.11	0.96-1.29	.17	0.60
Initial pulse oxygenation	1.12	0.94-1.33	.20	0.58
Lowest systolic BP	0.97	0.95-1.00	.04	0.60
Lowest MAP	0.97	0.94-1.00	.08	0.58
Largest heart rate (per 10 BPM)	1.7	1.34-2.16	<.001	0.74
Highest respiratory rate	1.1	1.00-1.22	.05	0.62
Highest fever	3.66	2.11-6.33	<.001	0.76
Highest fever >39°C	13.09	3.9-43.94	<.001	0.73

BPM, beats per minute; Ref, reference.