Table 1. Overview of small molecules... | American Society of Hematology

Table 1.

Overview of small molecules used in the study

Small molecule	Target	Proposed mode of action	Evidence	Source
MS452	CBX7	Prevents binding of chromodomain to H3K27me3	In vitro	24,27
EC-134	CBX7	Disrupt CBX7 chromodomain–histone tail interaction		AstraZeneca compound library
BDA-41	CBX7	ATCase inhibitor, which interacts with CBX7	In silico	26
UNC0642	EHMT1 and EHMT2	Blocks catalytic domain of the H3K9 methyltransferases EHMT1 and EHMT2	In vitro, in vivo	28

Small molecule	Target	Proposed mode of action	Evidence	Source
MS452	CBX7	Prevents binding of chromodomain to H3K27me3	In vitro	24,27
EC-134	CBX7	Disrupt CBX7 chromodomain–histone tail interaction		AstraZeneca compound library
BDA-41	CBX7	ATCase inhibitor, which interacts with CBX7	In silico	26
UNC0642	EHMT1 and EHMT2	Blocks catalytic domain of the H3K9 methyltransferases EHMT1 and EHMT2	In vitro, in vivo	28