Table 1. Thrombosis recurrence and... | American Society of Hematology

Table 1.

Thrombosis recurrence and bleeding rates in patients receiving long term versus limited anticoagulation as secondary prevention

	Thrombosis recurrence				Major bleeding incidence
	Long term AC	Limited AC	P value^**	Hazard ratio^***	Long term AC	Limited/ no AC	P value^**	APT and AC	P value versus AC alone^*****
De Stefano et al⁹ N = 206 total patients	5.3 per 100 py	12.8 per 100 py^*	0.008		2.4 per 100 py	0.7 per 100 py	0.08	3.8 per 100 py	0.50
De Stefano et al⁴ N = 494 total patients	N/R	N/R	N/R	0.31 (95% CI 0.13-0.69)	0.9% py	1.2% py	N/R	2.8% py	N/R
Hernández-Boluda et al¹⁰ N = 150 total patients	3.4 per 100 py	9.4 per 100 py	0.016	0.51 (95% CI 0.27-0.96)^****	1.8 per 100 py	1.5 per 100 py	0.8	N/R	N/R

	Thrombosis recurrence				Major bleeding incidence
	Long term AC	Limited AC	P value^**	Hazard ratio^***	Long term AC	Limited/ no AC	P value^**	APT and AC	P value versus AC alone^*****
De Stefano et al⁹ N = 206 total patients	5.3 per 100 py	12.8 per 100 py^*	0.008		2.4 per 100 py	0.7 per 100 py	0.08	3.8 per 100 py	0.50
De Stefano et al⁴ N = 494 total patients	N/R	N/R	N/R	0.31 (95% CI 0.13-0.69)	0.9% py	1.2% py	N/R	2.8% py	N/R
Hernández-Boluda et al¹⁰ N = 150 total patients	3.4 per 100 py	9.4 per 100 py	0.016	0.51 (95% CI 0.27-0.96)^****	1.8 per 100 py	1.5 per 100 py	0.8	N/R	N/R

Includes patients receiving long term AC with or without cytoreduction and/or with or without aspirin.

Reported P value comparing events among patients receiving AC therapy versus patients not on AC therapy.

Hazard ratio comparing long term AC therapy with aspirin.

Study reports incidence rate ratio.

Reported P value comparing incidence of major bleeding events in patients receiving AC versus dual AC and APT therapy.

HR, hazard ratio; N/R, not reported; py, patient-years.