Barriers and strategies for clinical trial accrual for AYA patients with examples of interventions
| Barrier themes . | Strategies that can address barriers . | Examples of intervention . | Exemplar papers/trials (PubMed) . |
|---|---|---|---|
| Communication amongst members of team | Forums to discuss cases Institutional policies Identifying unique AYA care Working groups | Tumor boards AYA champions AYA programs AYA working groups | PMID:3222270940 PMID: 3526464220 PMID: 3207778219 |
| Regulatory barriers | Share resources Assess workload/budget and staffing Stakeholder engagement | Shared IRB/central IRB Novel trial designs(basket/umbrella) Rapid activation of trials Committee with stakeholders | PMID:3204894141 PMID: 3224006842 |
| Physician barriers | Incentivize Educate Flexible institutional policies | AYA champions AYA tumor boards Incentives Educational opportunities | PMID: 2221313426 PMID: 2466935413 PMID: 3600667843 |
| Patient convenience | Make it easy for patient to get to the trial Take trial to patient Education regarding trials and resources | Patient navigation Community engagement Educational initiatives Social work support | PMID: 3878547438 PMID: 3429761135 PMID: 3648042544 PMID: 3490540545 PMID: 3060622446 PMID: 2917093047 |
| Institutional barriers | Policies that are flexible Age restrictions Standard operating procedures Channels of communication between peds and medical oncology | Incentivize institutions/scorecard AYA specific pathways for intake Screening procedures for enrollments | PMID: 3608985928 PMID: 3392671012 PMID: 3526464220 PMID: 3825291148 |
| Barrier themes . | Strategies that can address barriers . | Examples of intervention . | Exemplar papers/trials (PubMed) . |
|---|---|---|---|
| Communication amongst members of team | Forums to discuss cases Institutional policies Identifying unique AYA care Working groups | Tumor boards AYA champions AYA programs AYA working groups | PMID:3222270940 PMID: 3526464220 PMID: 3207778219 |
| Regulatory barriers | Share resources Assess workload/budget and staffing Stakeholder engagement | Shared IRB/central IRB Novel trial designs(basket/umbrella) Rapid activation of trials Committee with stakeholders | PMID:3204894141 PMID: 3224006842 |
| Physician barriers | Incentivize Educate Flexible institutional policies | AYA champions AYA tumor boards Incentives Educational opportunities | PMID: 2221313426 PMID: 2466935413 PMID: 3600667843 |
| Patient convenience | Make it easy for patient to get to the trial Take trial to patient Education regarding trials and resources | Patient navigation Community engagement Educational initiatives Social work support | PMID: 3878547438 PMID: 3429761135 PMID: 3648042544 PMID: 3490540545 PMID: 3060622446 PMID: 2917093047 |
| Institutional barriers | Policies that are flexible Age restrictions Standard operating procedures Channels of communication between peds and medical oncology | Incentivize institutions/scorecard AYA specific pathways for intake Screening procedures for enrollments | PMID: 3608985928 PMID: 3392671012 PMID: 3526464220 PMID: 3825291148 |