Table 1. T-cell lymphomas in patients... | American Society of Hematology

Table 1.

T-cell lymphomas in patients receiving CAR-Ts

Case reference	Vector	CAR target	Costim∗	Age, y	Latency,∗ mo	Tumor phenotype	Vector insertion(s)	Additional mutation(s) in tumor
Micklethwaite et al³⁸	piggyBac	CD19	4-1BB	66	3	CD3⁺CD4⁺	24 total, 1 ↑FYN	PIGA, multiple CNVs
Micklethwaite et al³⁸	piggyBac	CD19	4-1BB	30	12	CD3⁻CD8⁺	4 total, 1 ↑ lncRNA	Multiple CNVs
Harrison et al⁴⁰	LV	BCMA	4-1BB	51	5	CD3⁺CD4⁻CD8⁻	PBX2 3′ UTR	TET2, PTPRB, NFKB, germ line JAK3
Ozdemirli et al⁵	LV	BCMA	4-1BB	71	4	CD3⁺CD4⁺	SSU72 intron	KRAS, MYB, CBLC, ATM
Ghilardi et al⁴⁹	RV	CD19	CD28	64	3	CD3⁺CD4⁺	None	JAK3 VUS
Hamilton et al³	RV	CD19	CD28	59	2	CD3⁺CD4⁺EBV⁺	None	FYN, TET2, DNMT3A

Case reference	Vector	CAR target	Costim∗	Age, y	Latency,∗ mo	Tumor phenotype	Vector insertion(s)	Additional mutation(s) in tumor
Micklethwaite et al³⁸	piggyBac	CD19	4-1BB	66	3	CD3⁺CD4⁺	24 total, 1 ↑FYN	PIGA, multiple CNVs
Micklethwaite et al³⁸	piggyBac	CD19	4-1BB	30	12	CD3⁻CD8⁺	4 total, 1 ↑ lncRNA	Multiple CNVs
Harrison et al⁴⁰	LV	BCMA	4-1BB	51	5	CD3⁺CD4⁻CD8⁻	PBX2 3′ UTR	TET2, PTPRB, NFKB, germ line JAK3
Ozdemirli et al⁵	LV	BCMA	4-1BB	71	4	CD3⁺CD4⁺	SSU72 intron	KRAS, MYB, CBLC, ATM
Ghilardi et al⁴⁹	RV	CD19	CD28	64	3	CD3⁺CD4⁺	None	JAK3 VUS
Hamilton et al³	RV	CD19	CD28	59	2	CD3⁺CD4⁺EBV⁺	None	FYN, TET2, DNMT3A

CNV, copy number variation; UTR, untranslated region.

Costim, costimulatory domain used in the CAR construct; Latency, time from CAR-T infusion.