Table 3.

Association between clinical and environmental variables with the occurrence of hospitalization and ACU in patients with SCD from multivariate analyses

Aged up to 3 yAged up to 6 y
Model description Comparison model LRT P RN2 AIC AUC Model description Comparison model LRT P RN2 AIC AUC 
ACU = ED visits + hospitalizations ACU = ED visits + hospitalizations 
Base model NA NA 0.10 547 0.70 Base model NA NA 0.11 350 0.70 
Base model + E∗  vs base model 8 × 10–4 0.12 538 0.72 Base model + E†  vs base model .004 0.14 343 0.74 
Hospitalizations Hospitalizations 
Base model NA NA 0.09 526 0.68 Base model NA NA 0.13 373 0.72 
Base model + E∗  vs base model 2 × 10–4 0.12 514 0.72 Base model + E‡  vs base model 4 × 10–4 0.17 357 0.76 
Aged up to 3 yAged up to 6 y
Model description Comparison model LRT P RN2 AIC AUC Model description Comparison model LRT P RN2 AIC AUC 
ACU = ED visits + hospitalizations ACU = ED visits + hospitalizations 
Base model NA NA 0.10 547 0.70 Base model NA NA 0.11 350 0.70 
Base model + E∗  vs base model 8 × 10–4 0.12 538 0.72 Base model + E†  vs base model .004 0.14 343 0.74 
Hospitalizations Hospitalizations 
Base model NA NA 0.09 526 0.68 Base model NA NA 0.13 373 0.72 
Base model + E∗  vs base model 2 × 10–4 0.12 514 0.72 Base model + E‡  vs base model 4 × 10–4 0.17 357 0.76 

AIC, Akaike information criterion value; AUC, areas under the receiver operator characteristics curves; base model, hydroxyurea treatment + chronic transfusion + genotype; E, environmental factors; LRT P, P value calculated using likelihood ratio test; NA, not applicable; RN2, pseudo-R2 (RN2) values calculated based on the logistic regression model.

∗

E = % of households with children living >1 mile from a supermarket.

†

E = % of households with children living >1 mile from a supermarket + % of individuals with a bachelor’s degree.

‡

E = % of households with children living >1 mile from a supermarket + % of individuals with a bachelor’s degree.

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