Table 3.

TLS prophylactic strategies used in venetoclax escalation events in which TLS developed

Prophylactic agent usedNumber of patient-events
Allopurinol 8 (80%) 
Febuxostat 
IV hydration 4 (40%) 
IV diuretic use 1 (10%) 
Rasburicase 
Phosphate binders 5 (50%) 
Ion exchange resins 
Prophylactic agent usedNumber of patient-events
Allopurinol 8 (80%) 
Febuxostat 
IV hydration 4 (40%) 
IV diuretic use 1 (10%) 
Rasburicase 
Phosphate binders 5 (50%) 
Ion exchange resins 
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