Table 1.

Clinical and laboratory characteristics of patients with BDUC and HCs

BDUC
n = 375		HC
n = 100		P value
n (%)n (%)
Females 326 (87%) 70 (70%) <.001 
Family history of bleeding 130 (35%) 0 (0%) <.001 
Blood group O 173 (47%) 23 (30%) .007 
BDUC
n = 375		HC
n = 100		P value
n (%)n (%)
Females 326 (87%) 70 (70%) <.001 
Family history of bleeding 130 (35%) 0 (0%) <.001 
Blood group O 173 (47%) 23 (30%) .007 
Median (IQR)Median (IQR)
Age (y) 40.0 (29.0-54.0) 42.0 (28.0-52.0) .7 
BMI (kg/m2) 23.2 (20.8-26.3) 23.5 (20.7-25.5) .7 
Vicenza bleeding score 5.0 (4.0-8.0) 0.0 (0.0-0.0) <.001 
ISTH BAT bleeding score∗  6.0 (4.0-8.0) NA  
Above pathologic Vicenza cutoff†  250 (67%) 0 (0%) <.001 
Number of bleeding manifestations 3 (2-5) 0 (0-0) <.001 
Platelets (×109/L) 247 (211-286) 249 (221-286) .4 
Hemoglobin (g/dL) 13.5 (12.8-14.2) 13.9 (13.1-14.8) .023 
APTT (s) 35.4 (33.4-37.8) 34.3 (32.9-35.9) .002 
PT (%) 96 (88-105) 101 (92-107) .007 
Fibrinogen (mg/dL) 313 (271-360) 294 (257-338) .002 
Plasminogen (%)‡  102 (93-112) 102 (92-112) .7 
Median (IQR)Median (IQR)
Age (y) 40.0 (29.0-54.0) 42.0 (28.0-52.0) .7 
BMI (kg/m2) 23.2 (20.8-26.3) 23.5 (20.7-25.5) .7 
Vicenza bleeding score 5.0 (4.0-8.0) 0.0 (0.0-0.0) <.001 
ISTH BAT bleeding score∗  6.0 (4.0-8.0) NA  
Above pathologic Vicenza cutoff†  250 (67%) 0 (0%) <.001 
Number of bleeding manifestations 3 (2-5) 0 (0-0) <.001 
Platelets (×109/L) 247 (211-286) 249 (221-286) .4 
Hemoglobin (g/dL) 13.5 (12.8-14.2) 13.9 (13.1-14.8) .023 
APTT (s) 35.4 (33.4-37.8) 34.3 (32.9-35.9) .002 
PT (%) 96 (88-105) 101 (92-107) .007 
Fibrinogen (mg/dL) 313 (271-360) 294 (257-338) .002 
Plasminogen (%)‡  102 (93-112) 102 (92-112) .7 

bold if signficant p<0.05

NA, not available.

∗

Available for 201 (53.6%) patients with BDUC.

†

The cutoff for females was ≥5 and ≥3 for males.

‡

Available for 218 patients and 19 HCs.

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