Percent changes in Tyr-p-bd3, PTP1B, and ankyrin-1 in response to AG-348 at various longitudinal time points
| . | % Change from baseline . | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5 mg . | 20 mg . | 50 mg . | 100 mg . | End of taper . | EOS . | |||||||||||||
| n . | Mean (SE) . | P value . | n . | Mean (SE) . | P value . | n . | Mean (SE) . | P value . | n . | Mean (SE) . | P value . | n . | Mean (SE) . | P value . | n . | Mean (SE) . | P value . | |
| Tyr-p-bd3 | 15 | –20.0% (13.0%) | .13 | 15 | –34.0% (13.0%) | .01 | 15 | –42.0% (13.0%) | .002 | 9 | –42.0% (14.0%) | .004 | 15 | –29.0% (13.0%) | .03 | 15 | –3.0% (13.0%) | .84 |
| PTP1B | 15 | 51.0% (21.0%) | .02 | 15 | 72.0% (21.0%) | .0009 | 15 | 72.0% (21.0%) | .001 | 9 | 99.0% (22.0%) | <.0001 | 15 | 57.0% (21.0%) | .007 | 15 | 32.0% (21.0%) | .13 |
| Ankyrin-1 | 11 | –3.0% (48.0%) | .95 | 11 | 36.0% (48.0%) | .45 | 11 | 82.0% (48.0%) | .09 | 7 | 78.0% (50.0%) | .13 | 11 | 45.0% (48.0%) | .35 | 11 | –4.0% (48.0%) | .94 |
| . | % Change from baseline . | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5 mg . | 20 mg . | 50 mg . | 100 mg . | End of taper . | EOS . | |||||||||||||
| n . | Mean (SE) . | P value . | n . | Mean (SE) . | P value . | n . | Mean (SE) . | P value . | n . | Mean (SE) . | P value . | n . | Mean (SE) . | P value . | n . | Mean (SE) . | P value . | |
| Tyr-p-bd3 | 15 | –20.0% (13.0%) | .13 | 15 | –34.0% (13.0%) | .01 | 15 | –42.0% (13.0%) | .002 | 9 | –42.0% (14.0%) | .004 | 15 | –29.0% (13.0%) | .03 | 15 | –3.0% (13.0%) | .84 |
| PTP1B | 15 | 51.0% (21.0%) | .02 | 15 | 72.0% (21.0%) | .0009 | 15 | 72.0% (21.0%) | .001 | 9 | 99.0% (22.0%) | <.0001 | 15 | 57.0% (21.0%) | .007 | 15 | 32.0% (21.0%) | .13 |
| Ankyrin-1 | 11 | –3.0% (48.0%) | .95 | 11 | 36.0% (48.0%) | .45 | 11 | 82.0% (48.0%) | .09 | 7 | 78.0% (50.0%) | .13 | 11 | 45.0% (48.0%) | .35 | 11 | –4.0% (48.0%) | .94 |
Percent changes were calculated from baseline (visit 1, before drug initiation) and were computed from a longitudinal regression model that was adjusted for age and sex.
SE, standard error.