CEs according to GVHD prophylaxis and donor type
| . | PTCY-based prophylaxis n = 456 . | Other GVHD prophylaxis n = 558 . | P value . |
|---|---|---|---|
| ECEs | N = 35 | N = 14 | <.001 |
| ECEs | 35 (100%) | 14 (100%) | |
| Median of days to diagnosis (IQR) | 15 (8-49) | 11 (6-24) | .964 |
| Type of CE | |||
| Arrhythmia | 11 (31.4) | 10 (71.4) | .088 |
| Heart failure | 9 (25.7) | 0 | |
| Myocardial ischemia | 3 (8.6) | 1 (7.1) | |
| Pericardial disorders | 11 (31.4) | 3 (21.4) | |
| Other | 1 (2.9) | 0 | |
| Grade of severity (CTCAE) | |||
| 1-2 | 19 (54.3) | 12 (85.7) | .102 |
| 3-4 | 12 (34.3) | 2 (14.3) | |
| 5 | 4 (11.4) | 0 | |
| Mortality rate | |||
| Day 30 | 4 (11.4) | 1 (7.1) | .382 |
| Day 60 | 7 (22.9) | 1 (7.1) | .049 |
| LCEs | N = 21 | N = 14 | .643 |
| LCEs | 21 (100%) | 24 (100%) | |
| Time to diagnosis, y, median | 2.8 (1.9-5.4) | 4.5 (2.1-5.4) | .889 |
| Type of CE | |||
| Arrhythmia | 3 (14.2) | 5 (20.8) | .796 |
| Heart failure | 8 (38.0) | 9 (37.5) | |
| Myocardial ischemia | 4 (19.0) | 4 (16.7) | |
| Pericardial disorders | 5 (23.8) | 5 (20.8) | |
| Other | 1 (0.1) | 1 (4.2) | |
| Grade of severity (CTCAE) | |||
| 1-2 | 15 (62.5) | 14 (66.7) | |
| 3-4 | 9 (37.5) | 5 (20.8) | .224 |
| 5 | 0 | 2 (8.3) | |
| Mortality rate | |||
| Day 30 | 2 (9.5) | 3 (12.5) | |
| Day 60 | 2 (9.5) | 4 (16.7) | .667 |
| . | PTCY-based prophylaxis n = 456 . | Other GVHD prophylaxis n = 558 . | P value . |
|---|---|---|---|
| ECEs | N = 35 | N = 14 | <.001 |
| ECEs | 35 (100%) | 14 (100%) | |
| Median of days to diagnosis (IQR) | 15 (8-49) | 11 (6-24) | .964 |
| Type of CE | |||
| Arrhythmia | 11 (31.4) | 10 (71.4) | .088 |
| Heart failure | 9 (25.7) | 0 | |
| Myocardial ischemia | 3 (8.6) | 1 (7.1) | |
| Pericardial disorders | 11 (31.4) | 3 (21.4) | |
| Other | 1 (2.9) | 0 | |
| Grade of severity (CTCAE) | |||
| 1-2 | 19 (54.3) | 12 (85.7) | .102 |
| 3-4 | 12 (34.3) | 2 (14.3) | |
| 5 | 4 (11.4) | 0 | |
| Mortality rate | |||
| Day 30 | 4 (11.4) | 1 (7.1) | .382 |
| Day 60 | 7 (22.9) | 1 (7.1) | .049 |
| LCEs | N = 21 | N = 14 | .643 |
| LCEs | 21 (100%) | 24 (100%) | |
| Time to diagnosis, y, median | 2.8 (1.9-5.4) | 4.5 (2.1-5.4) | .889 |
| Type of CE | |||
| Arrhythmia | 3 (14.2) | 5 (20.8) | .796 |
| Heart failure | 8 (38.0) | 9 (37.5) | |
| Myocardial ischemia | 4 (19.0) | 4 (16.7) | |
| Pericardial disorders | 5 (23.8) | 5 (20.8) | |
| Other | 1 (0.1) | 1 (4.2) | |
| Grade of severity (CTCAE) | |||
| 1-2 | 15 (62.5) | 14 (66.7) | |
| 3-4 | 9 (37.5) | 5 (20.8) | .224 |
| 5 | 0 | 2 (8.3) | |
| Mortality rate | |||
| Day 30 | 2 (9.5) | 3 (12.5) | |
| Day 60 | 2 (9.5) | 4 (16.7) | .667 |
| CEs according to donor type . | % (95% CI) . | % (95% CI) . | P value . |
|---|---|---|---|
| HLA-matched donors (MSD and MUD) | |||
| Total patients (n = 661) | 163 (35.4) | 495 (88.6) | <.001 |
| Day +100 cumulative incidence of ECE | 7.4 (4.0-12.1) | 2.8 (1.6-4.6) | .009 |
| 3-y cumulative incidence of LCE | 2.9 (1.0-6.8) | 4.4 (2.8-6.7) | .413 |
| HLA-mismatched unrelated donors | |||
| Total patients (n = 86) | 30 (6.5) | 56 (10.0) | N/A |
| Day +100 cumulative incidence of ECE | 0 | 0 | |
| 3-y cumulative incidence of LCE | Only 1 patient; 6 y after allo-HCT | 0 | |
| Haploidentical donors | |||
| Total patients (n = 273) | 268 (58.1) | 5 (0.9) | < .001 |
| Day +100 cumulative incidence of ECE | 8.6 (5.6-12.4) | 0 | .495 |
| 3-y cumulative incidence of LCE | 6.1 (3.3-10.1) | 0 | .583 |
| CEs according to donor type . | % (95% CI) . | % (95% CI) . | P value . |
|---|---|---|---|
| HLA-matched donors (MSD and MUD) | |||
| Total patients (n = 661) | 163 (35.4) | 495 (88.6) | <.001 |
| Day +100 cumulative incidence of ECE | 7.4 (4.0-12.1) | 2.8 (1.6-4.6) | .009 |
| 3-y cumulative incidence of LCE | 2.9 (1.0-6.8) | 4.4 (2.8-6.7) | .413 |
| HLA-mismatched unrelated donors | |||
| Total patients (n = 86) | 30 (6.5) | 56 (10.0) | N/A |
| Day +100 cumulative incidence of ECE | 0 | 0 | |
| 3-y cumulative incidence of LCE | Only 1 patient; 6 y after allo-HCT | 0 | |
| Haploidentical donors | |||
| Total patients (n = 273) | 268 (58.1) | 5 (0.9) | < .001 |
| Day +100 cumulative incidence of ECE | 8.6 (5.6-12.4) | 0 | .495 |
| 3-y cumulative incidence of LCE | 6.1 (3.3-10.1) | 0 | .583 |