Risk factors for LCEs
| MVA . | Risk for LCEs . | P value . |
|---|---|---|
| HR (95% CI) . | ||
| Age, y | ||
| >50 (vs younger) | 2.00 (0.84-4.76) | .117 |
| HTN | ||
| Yes (vs no) | 1.42 (0.73-2.79) | .296 |
| DLP | ||
| Yes (vs no) | 2.01 (1.01-4.01) | .046 |
| Diabetes mellitus | ||
| Yes (vs no) | 0.88 (0.32-2.39) | .814 |
| Previous cardiac pathology | ||
| Yes (vs no) | 2.43 (1.19-4.96) | .014 |
| Obesity (BMI ≥30) | ||
| Yes (vs no) | 3.24 (1.41-7.45) | .005 |
| Conditioning regimen | ||
| MAC regimen containing CY (vs others) | 0.37 (0.08-1.60) | .187 |
| GVHD prophylaxis | ||
| PTCY-based prophylaxis (vs other) | 1.06 (0.42-2.67) | .892 |
| Donor type | ||
| Haploidentical donors (vs HLA-matched and MMUD) | 1.59 (0.60-4.22) | .342 |
| History of grade 2-4 aGVHD | ||
| Yes (vs no) | 2.14 (1.13-4.05) | .018 |
| Moderate/severe cGVHD | ||
| Time-dependent variable | 0.73 (0.21-2.53) | .621 |
| MVA . | Risk for LCEs . | P value . |
|---|---|---|
| HR (95% CI) . | ||
| Age, y | ||
| >50 (vs younger) | 2.00 (0.84-4.76) | .117 |
| HTN | ||
| Yes (vs no) | 1.42 (0.73-2.79) | .296 |
| DLP | ||
| Yes (vs no) | 2.01 (1.01-4.01) | .046 |
| Diabetes mellitus | ||
| Yes (vs no) | 0.88 (0.32-2.39) | .814 |
| Previous cardiac pathology | ||
| Yes (vs no) | 2.43 (1.19-4.96) | .014 |
| Obesity (BMI ≥30) | ||
| Yes (vs no) | 3.24 (1.41-7.45) | .005 |
| Conditioning regimen | ||
| MAC regimen containing CY (vs others) | 0.37 (0.08-1.60) | .187 |
| GVHD prophylaxis | ||
| PTCY-based prophylaxis (vs other) | 1.06 (0.42-2.67) | .892 |
| Donor type | ||
| Haploidentical donors (vs HLA-matched and MMUD) | 1.59 (0.60-4.22) | .342 |
| History of grade 2-4 aGVHD | ||
| Yes (vs no) | 2.14 (1.13-4.05) | .018 |
| Moderate/severe cGVHD | ||
| Time-dependent variable | 0.73 (0.21-2.53) | .621 |
Cumulative incidence analysis accounted for death and relapse as competing events. Any LCE occurring after disease relapse was not accounted. The present analysis has been done using landmark analysis. No event diagnosed before day +100 has been accounted. Variables included in the multivariate model were selected based on results reported in supplemental Table 2 and if considered clinically relevant for cardiac toxicity according to previous related publications.
BMI, body mass index; MMUD, mismatched unrelated donor.