Risk factors for ECEs
| MVA . | Risk for ECEs, HR (95% CI) . | P value . |
|---|---|---|
| Age, y | ||
| > 60 (vs younger) | 1.36 (0.74-2.50) | .315 |
| HTN | ||
| Yes (vs no) | 2.01 (1.06-3.80) | .030 |
| DLP | ||
| Yes (vs no) | 2.42 (1.20-4.86) | .012 |
| Diabetes mellitus | ||
| Yes (vs no) | 0.49 (0.16-1.44) | .197 |
| Previous cardiac pathology | ||
| Yes (vs no) | 1.39 (0.68-2.85) | .355 |
| Disease status before allo-HCT | ||
| Active disease (vs complete remission) | 1.70 (0.77-3.75) | .182 |
| Conditioning regimen | ||
| MAC regimen containing CY (vs others) | 0.85 (0.30-2.42) | .773 |
| GVHD prophylaxis | ||
| PTCY-based prophylaxis (vs other) | 2.86 (1.32-6.21) | .007 |
| Donor type | ||
| Haploidentical donors (vs HLA-matched and MMUD) | 1.16 (0.57-2.39) | .674 |
| Grade 3-4 aGVHD | ||
| Time-dependent variable | 2.19 (0.88-5.43) | .088 |
| MVA . | Risk for ECEs, HR (95% CI) . | P value . |
|---|---|---|
| Age, y | ||
| > 60 (vs younger) | 1.36 (0.74-2.50) | .315 |
| HTN | ||
| Yes (vs no) | 2.01 (1.06-3.80) | .030 |
| DLP | ||
| Yes (vs no) | 2.42 (1.20-4.86) | .012 |
| Diabetes mellitus | ||
| Yes (vs no) | 0.49 (0.16-1.44) | .197 |
| Previous cardiac pathology | ||
| Yes (vs no) | 1.39 (0.68-2.85) | .355 |
| Disease status before allo-HCT | ||
| Active disease (vs complete remission) | 1.70 (0.77-3.75) | .182 |
| Conditioning regimen | ||
| MAC regimen containing CY (vs others) | 0.85 (0.30-2.42) | .773 |
| GVHD prophylaxis | ||
| PTCY-based prophylaxis (vs other) | 2.86 (1.32-6.21) | .007 |
| Donor type | ||
| Haploidentical donors (vs HLA-matched and MMUD) | 1.16 (0.57-2.39) | .674 |
| Grade 3-4 aGVHD | ||
| Time-dependent variable | 2.19 (0.88-5.43) | .088 |
Variables included in the multivariate model were selected based on results reported in supplemental Table 1 (univariate regression analysis) and if considered clinically relevant for cardiac toxicity according to previous related publications. Posttransplant follow-up has been censored at 100 days. No event diagnosed after day +100 has been accounted for this analysis.
MMUD, mismatched unrelated donor.