Early and late CEs: detailed information
| . | n (%) . | Grade of severity (CTCAE) . | Median days to diagnosis (IQR) . | Additional comment . | Death secondary to CAE . | Day +30 mortality rate . | Day +60 mortality rate . | |
|---|---|---|---|---|---|---|---|---|
| All patients with ECEs | 49 (100) | 1-2 3-4 5 | 30 (61.2) 14 (30.6) 4 (8.1) | 13 (7-44) | N/A | 4 (8.1) | 5 (10.2) | 8 (16.3) |
| Heart failure | 9 (18.4) | 1-2 3-4 5 | 4 (44.4) 3 (33.3) 2 (22.2) | 14 (12-50) | One (11.1) case presented with cardiac pulmonary edema | 2 (22.2) | 2 (22.2) | 3 (33.3) |
| Myocardial infarction or ischemia | 4 (8.2) | 1-2 3-4 5 | 1 (25.0) 3 (75.0) 0 | 9 (3-75) | Two (50.0%) required percutaneal revascularization | 0 | 0 | 0 |
| Arrythmia | 21 (42.9) | 1-2 3-4 5 | 15 (71.4) 4 (19.0) 2 (9.5) | 12 (7-21) | All supraventricular arrythmias | 2 (9.5) | 2 (9.5) | 3 (14.2) |
| Pericardiac effusion or pericarditis | 14 (28.6) | 1-2 3-4 5 | 10 (71.4) 4 (28.6) 0 | 21 (3-75) | 6 (42.8%) cases were diagnosed with pericarditis. Four (28.6%) cases required pericardial drain. No patient received TBI. | 0 | 1 (7.1) | 2 (14.2) |
| Others | 1 (2.0) | 1-2 3-4 5 | 0 1 (100) 0 | 35 | Auricular thrombus | 0 | 0 | 0 |
| . | n (%) . | Grade of severity (CTCAE) . | Median days to diagnosis (IQR) . | Additional comment . | Death secondary to CAE . | Day +30 mortality rate . | Day +60 mortality rate . | |
|---|---|---|---|---|---|---|---|---|
| All patients with ECEs | 49 (100) | 1-2 3-4 5 | 30 (61.2) 14 (30.6) 4 (8.1) | 13 (7-44) | N/A | 4 (8.1) | 5 (10.2) | 8 (16.3) |
| Heart failure | 9 (18.4) | 1-2 3-4 5 | 4 (44.4) 3 (33.3) 2 (22.2) | 14 (12-50) | One (11.1) case presented with cardiac pulmonary edema | 2 (22.2) | 2 (22.2) | 3 (33.3) |
| Myocardial infarction or ischemia | 4 (8.2) | 1-2 3-4 5 | 1 (25.0) 3 (75.0) 0 | 9 (3-75) | Two (50.0%) required percutaneal revascularization | 0 | 0 | 0 |
| Arrythmia | 21 (42.9) | 1-2 3-4 5 | 15 (71.4) 4 (19.0) 2 (9.5) | 12 (7-21) | All supraventricular arrythmias | 2 (9.5) | 2 (9.5) | 3 (14.2) |
| Pericardiac effusion or pericarditis | 14 (28.6) | 1-2 3-4 5 | 10 (71.4) 4 (28.6) 0 | 21 (3-75) | 6 (42.8%) cases were diagnosed with pericarditis. Four (28.6%) cases required pericardial drain. No patient received TBI. | 0 | 1 (7.1) | 2 (14.2) |
| Others | 1 (2.0) | 1-2 3-4 5 | 0 1 (100) 0 | 35 | Auricular thrombus | 0 | 0 | 0 |
| . | N (%) . | Grade of severity (CTCAE) . | Median months to diagnosis (IQR) . | Additional comment . | Death secondary to CAE . | Day +30 mortality rate . | Day +60 mortality rate . | |
|---|---|---|---|---|---|---|---|---|
| All patients with LCEs | 45 (100) | 1-2 3-4 5 | 29 (64.4) 14 (31.1) 2 (4.4) | 17.5 (7.9-34.7) | N/A | 2 (4.4) | 5 (11.1) | 6 (13.3) |
| Heart failure | 17 (37.8) | 1-2 3-4 5 | 15 (88.2) 2 (11.7) 0 | 16.9 (7.4-40.3) | 0 | 1 (5.8) | 1 (5.8) | |
| Myocardial infarction or ischemia | 8 (17.8) | 1-2 3-4 5 | 2 (25.0) 5 (62.5) 1 (12.5) | 38.7 (21.2-60.8) | Two (22.2%) cases of angina pectoris; 2 (22.2%) cases required percutaneal revascularization | 1 (12.5) | 1 (12.5) | 1 (12.5) |
| Arrythmia | 8 (17.8) | 1-2 3-4 5 | 7 (87.5) 1 (12.5) 0 | 6.3 (3.7-21.0) | All supraventricular | 0 | 2 (25.0) | 3 (37.5) |
| Pericardiac effusion or pericarditis | 10 (22.2) | 1-2 3-4 5 | 4 (40.0) 5 (50.0) 1 (10.0) | 12.9 (8.4-34.5) | Five episodes were diagnosed with pericarditis. Of 5 patients with pericardial effusion, 1 adult died because of cardiac tamponade. | 1 (10.0) | 1 (10.0) | 1 (10.0) |
| Other: moderate valvopathy | 2 (4.4) | 1-2 3-4 5 | 2 (100) 0 0 | 18.2 (12.3-18.2) | 0 | 0 | 0 | |
| . | N (%) . | Grade of severity (CTCAE) . | Median months to diagnosis (IQR) . | Additional comment . | Death secondary to CAE . | Day +30 mortality rate . | Day +60 mortality rate . | |
|---|---|---|---|---|---|---|---|---|
| All patients with LCEs | 45 (100) | 1-2 3-4 5 | 29 (64.4) 14 (31.1) 2 (4.4) | 17.5 (7.9-34.7) | N/A | 2 (4.4) | 5 (11.1) | 6 (13.3) |
| Heart failure | 17 (37.8) | 1-2 3-4 5 | 15 (88.2) 2 (11.7) 0 | 16.9 (7.4-40.3) | 0 | 1 (5.8) | 1 (5.8) | |
| Myocardial infarction or ischemia | 8 (17.8) | 1-2 3-4 5 | 2 (25.0) 5 (62.5) 1 (12.5) | 38.7 (21.2-60.8) | Two (22.2%) cases of angina pectoris; 2 (22.2%) cases required percutaneal revascularization | 1 (12.5) | 1 (12.5) | 1 (12.5) |
| Arrythmia | 8 (17.8) | 1-2 3-4 5 | 7 (87.5) 1 (12.5) 0 | 6.3 (3.7-21.0) | All supraventricular | 0 | 2 (25.0) | 3 (37.5) |
| Pericardiac effusion or pericarditis | 10 (22.2) | 1-2 3-4 5 | 4 (40.0) 5 (50.0) 1 (10.0) | 12.9 (8.4-34.5) | Five episodes were diagnosed with pericarditis. Of 5 patients with pericardial effusion, 1 adult died because of cardiac tamponade. | 1 (10.0) | 1 (10.0) | 1 (10.0) |
| Other: moderate valvopathy | 2 (4.4) | 1-2 3-4 5 | 2 (100) 0 0 | 18.2 (12.3-18.2) | 0 | 0 | 0 | |
CEs were classified as ECEs or LCEs depending on whether it was diagnosed during the first 100 days after transplant, or it was diagnosed after day 100. Only the first CE occurring in patients included in the study was accounted in the analysis. CEs occurring after presenting disease relapse after allo-HCT were not accounted. LCEs were considered if diagnosed after day +100 and in patients without prior history of ECE.
TBI, total body irradiation.