Safety of NKTR-255
| Adverse effect . | Cycle 1 (n = 9 infusions), n (%) . | Subsequent cycles (n = 12 infusions), n (%) . | ||||||
|---|---|---|---|---|---|---|---|---|
| Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | |
| Anemia | — | 4 (44) | — | — | 1 (8) | — | 1 (8) | — |
| Neutropenia | — | — | 2 (22) | 2 (22) | 2 (17) | — | 1 (8) | — |
| Thrombocytopenia | 4 (44) | — | — | 1 (11) | 1 (8) | — | — | — |
| Fevers | 4 (44) | 1 (11) | — | — | 5 (42) | — | — | — |
| Chills | 2 (22) | — | — | — | 2 (17) | — | — | — |
| Nausea | 2 (22) | — | — | — | — | — | — | — |
| Vomiting | 1 (11) | — | — | — | — | — | — | — |
| Myalgias | — | — | — | — | 2 (17) | — | — | — |
| Infusion reaction | 1 (11) | 1 (11) | — | — | — | — | — | — |
| Fatigue | — | 1 (11) | — | — | — | — | — | — |
| Headache | — | 1 (11) | — | — | — | — | — | — |
| Dizziness | 1 (11) | — | — | — | — | — | — | — |
| Sinus tachycardia | 1 (11) | — | — | — | — | — | — | — |
| Hypotension | — | — | — | — | — | — | 1 (8) | — |
| Dyspnea | — | — | — | — | — | — | 1 (8) | — |
| Hypoxia | — | — | — | — | — | — | 1 (8) | — |
| Diarrhea | — | — | — | — | — | 1 (8) | — | — |
| Adverse effect . | Cycle 1 (n = 9 infusions), n (%) . | Subsequent cycles (n = 12 infusions), n (%) . | ||||||
|---|---|---|---|---|---|---|---|---|
| Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | |
| Anemia | — | 4 (44) | — | — | 1 (8) | — | 1 (8) | — |
| Neutropenia | — | — | 2 (22) | 2 (22) | 2 (17) | — | 1 (8) | — |
| Thrombocytopenia | 4 (44) | — | — | 1 (11) | 1 (8) | — | — | — |
| Fevers | 4 (44) | 1 (11) | — | — | 5 (42) | — | — | — |
| Chills | 2 (22) | — | — | — | 2 (17) | — | — | — |
| Nausea | 2 (22) | — | — | — | — | — | — | — |
| Vomiting | 1 (11) | — | — | — | — | — | — | — |
| Myalgias | — | — | — | — | 2 (17) | — | — | — |
| Infusion reaction | 1 (11) | 1 (11) | — | — | — | — | — | — |
| Fatigue | — | 1 (11) | — | — | — | — | — | — |
| Headache | — | 1 (11) | — | — | — | — | — | — |
| Dizziness | 1 (11) | — | — | — | — | — | — | — |
| Sinus tachycardia | 1 (11) | — | — | — | — | — | — | — |
| Hypotension | — | — | — | — | — | — | 1 (8) | — |
| Dyspnea | — | — | — | — | — | — | 1 (8) | — |
| Hypoxia | — | — | — | — | — | — | 1 (8) | — |
| Diarrhea | — | — | — | — | — | 1 (8) | — | — |