Recommendations for response assessment
| Category of response . | Recommendations . |
|---|---|
| All | Report changes as a continuous measurement, wherever possible |
| Correlate response with overall survival for each treatment tested | |
| Explore interactions between types of response to determine which are independently predictive of clinical outcomes | |
| Molecular | Calculate relative vs absolute changes in VAF |
| Compare changes in nondriver mutations as well as JAK2/MPL/CALR | |
| When mutations are no longer detectable include the assay limit of detection | |
| Spleen volume | Consider residual normal spleen volume as baseline when calculating SVR |
| Compare prognostic effect of relative vs absolute changes in spleen volume | |
| Incorporate volumetric assessment of spleen in routine practice, wherever possible | |
| Histomorphometry | Explore computational image analysis to enable more objective quantification of histological changes |
| Undertake exploratory analysis to identify early biomarkers of treatment effect | |
| Cytokines | Determine whether cytokine responses correlate with overall survival |
| Category of response . | Recommendations . |
|---|---|
| All | Report changes as a continuous measurement, wherever possible |
| Correlate response with overall survival for each treatment tested | |
| Explore interactions between types of response to determine which are independently predictive of clinical outcomes | |
| Molecular | Calculate relative vs absolute changes in VAF |
| Compare changes in nondriver mutations as well as JAK2/MPL/CALR | |
| When mutations are no longer detectable include the assay limit of detection | |
| Spleen volume | Consider residual normal spleen volume as baseline when calculating SVR |
| Compare prognostic effect of relative vs absolute changes in spleen volume | |
| Incorporate volumetric assessment of spleen in routine practice, wherever possible | |
| Histomorphometry | Explore computational image analysis to enable more objective quantification of histological changes |
| Undertake exploratory analysis to identify early biomarkers of treatment effect | |
| Cytokines | Determine whether cytokine responses correlate with overall survival |