Multivariable Cox proportional cause-specific hazards models for association between permissive and nonpermissive HLA-DPB1 mismatches and aGVHD, NRM, and disease relapse using different TCE stratification strategies
| End point . | TCE (standard) . | TCE core/noncore . | TCE core/noncore (directional) . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| DPB1 matching . | HR (99% CI) . | P value . | DPB1 matching . | HR (99% CI) . | P value . | DPB1 matching . | HR (99% CI) . | P value . | |
| aGVHD 2-4 | Match | 1 | Match | 1 | Match | 1 | |||
| Permissive | 1.23 (1.07-1.41) | <.001 | Core permissive | 1.05 (0.88-1.24) | .5 | Core permissive | 1.05 (0.88-1.24) | .5 | |
| Noncore permissive | 1.36 (1.16-1.60) | <.0001 | Noncore permissive HVG | 1.11 (0.88-1.39) | .3 | ||||
| Noncore permissive GVH | 1.55 (1.28-1.86) | <.0001 | |||||||
| Nonpermissive | 1.40 (1.21-1.61) | <.0001 | Nonpermissive | 1.39 (1.21-1.61) | <.0001 | Nonpermissive HVG | 1.28 (1.05-1.55) | .001 | |
| Nonpermissive GVH | 1.46 (1.25-1.71) | <.0001 | |||||||
| aGVHD 3-4 | Match | 1 | Match | 1 | Match | 1 | |||
| Permissive | 1.25 (0.99-1.59) | .014 | Core permissive | 1.11 (0.83-1.48) | .4 | Core permissive | 1.11 (0.83-1.48) | .4 | |
| Noncore permissive | 1.36 (1.03-1.80) | .005 | Noncore permissive HVG | 1.27 (0.87-1.86) | .1 | ||||
| Noncore permissive GVH | 1.42 (1.03-1.96) | .005 | |||||||
| Nonpermissive | 1.48 (1.16-1.90) | <.0001 | Nonpermissive | 1.48 (1.16-1.90) | <.0001 | Nonpermissive HVG | 1.52 (1.11-2.09) | <.001 | |
| Nonpermissive GVH | 1.46 (1.11-1.92) | <.001 | |||||||
| NRM | Match | 1 | Match | 1 | Match | 1 | |||
| Permissive | 1.12 (0.94-1.33) | .09 | Core permissive | 1.09 (0.89-1.34) | .3 | Core permissive | 1.09 (0.89-1.34) | .3 | |
| Noncore permissive | 1.11 (0.90-1.37) | .2 | Noncore permissive HVG | 1.21 (0.91-1.59) | .08 | ||||
| Noncore permissive GVH | 1.05 (0.82-1.35) | .6 | |||||||
| Nonpermissive | 1.26 (1.05-1.50) | .001 | Nonpermissive | 1.26 (1.05-1.50) | .001 | Nonpermissive HVG | 1.17 (0.92-1.48) | .09 | |
| Nonpermissive GVH | 1.31 (1.07-1.59) | <.001 | |||||||
| Relapse | Match | 1 | Match | 1 | Match | 1 | |||
| Permissive | 0.87 (0.77-0.99) | .007 | Core permissive | 0.93 (0.80-1.08) | .2 | Core permissive | 0.93 (0.80-1.08) | .2 | |
| Noncore permissive | 0.83 (0.71-0.97) | .003 | Noncore permissive HVG | 0.93 (0.75-1.15) | .4 | ||||
| Noncore permissive GVH | 0.77 (0.63-0.94) | <.001 | |||||||
| Nonpermissive | 0.77 (0.67-0.88) | <.0001 | Nonpermissive | 0.77 (0.67-0.88) | <.0001 | Nonpermissive HVG | 0.83 (0.69-1.00) | .010 | |
| Nonpermissive GVH | 0.73 (0.63-0.86) | <.0001 | |||||||
| End point . | TCE (standard) . | TCE core/noncore . | TCE core/noncore (directional) . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| DPB1 matching . | HR (99% CI) . | P value . | DPB1 matching . | HR (99% CI) . | P value . | DPB1 matching . | HR (99% CI) . | P value . | |
| aGVHD 2-4 | Match | 1 | Match | 1 | Match | 1 | |||
| Permissive | 1.23 (1.07-1.41) | <.001 | Core permissive | 1.05 (0.88-1.24) | .5 | Core permissive | 1.05 (0.88-1.24) | .5 | |
| Noncore permissive | 1.36 (1.16-1.60) | <.0001 | Noncore permissive HVG | 1.11 (0.88-1.39) | .3 | ||||
| Noncore permissive GVH | 1.55 (1.28-1.86) | <.0001 | |||||||
| Nonpermissive | 1.40 (1.21-1.61) | <.0001 | Nonpermissive | 1.39 (1.21-1.61) | <.0001 | Nonpermissive HVG | 1.28 (1.05-1.55) | .001 | |
| Nonpermissive GVH | 1.46 (1.25-1.71) | <.0001 | |||||||
| aGVHD 3-4 | Match | 1 | Match | 1 | Match | 1 | |||
| Permissive | 1.25 (0.99-1.59) | .014 | Core permissive | 1.11 (0.83-1.48) | .4 | Core permissive | 1.11 (0.83-1.48) | .4 | |
| Noncore permissive | 1.36 (1.03-1.80) | .005 | Noncore permissive HVG | 1.27 (0.87-1.86) | .1 | ||||
| Noncore permissive GVH | 1.42 (1.03-1.96) | .005 | |||||||
| Nonpermissive | 1.48 (1.16-1.90) | <.0001 | Nonpermissive | 1.48 (1.16-1.90) | <.0001 | Nonpermissive HVG | 1.52 (1.11-2.09) | <.001 | |
| Nonpermissive GVH | 1.46 (1.11-1.92) | <.001 | |||||||
| NRM | Match | 1 | Match | 1 | Match | 1 | |||
| Permissive | 1.12 (0.94-1.33) | .09 | Core permissive | 1.09 (0.89-1.34) | .3 | Core permissive | 1.09 (0.89-1.34) | .3 | |
| Noncore permissive | 1.11 (0.90-1.37) | .2 | Noncore permissive HVG | 1.21 (0.91-1.59) | .08 | ||||
| Noncore permissive GVH | 1.05 (0.82-1.35) | .6 | |||||||
| Nonpermissive | 1.26 (1.05-1.50) | .001 | Nonpermissive | 1.26 (1.05-1.50) | .001 | Nonpermissive HVG | 1.17 (0.92-1.48) | .09 | |
| Nonpermissive GVH | 1.31 (1.07-1.59) | <.001 | |||||||
| Relapse | Match | 1 | Match | 1 | Match | 1 | |||
| Permissive | 0.87 (0.77-0.99) | .007 | Core permissive | 0.93 (0.80-1.08) | .2 | Core permissive | 0.93 (0.80-1.08) | .2 | |
| Noncore permissive | 0.83 (0.71-0.97) | .003 | Noncore permissive HVG | 0.93 (0.75-1.15) | .4 | ||||
| Noncore permissive GVH | 0.77 (0.63-0.94) | <.001 | |||||||
| Nonpermissive | 0.77 (0.67-0.88) | <.0001 | Nonpermissive | 0.77 (0.67-0.88) | <.0001 | Nonpermissive HVG | 0.83 (0.69-1.00) | .010 | |
| Nonpermissive GVH | 0.73 (0.63-0.86) | <.0001 | |||||||
Multivariable models were adjusted for patient and donor age, sex (mis)matching, cytomegalovirus serostatus matching, HCT comorbidity score,22 Karnofsky performance score, disease at transplant, disease risk index,23 year of HCT, stem cell source, conditioning regimen and use of total-body irradiation, use of in vivo T-cell depletion, and GVHD prophylaxis regimen.