Table 3.

Tests to evaluate liver health

Blood tests  
ALT, AST Measures hepatocyte damage and liver inflammation 
APRI Measures liver fibrosis based on AST/platelet count ratio 
FIB-4 Measures liver fibrosis based on (age × AST)/ (platelet × √ALT) 
Fibrosure (Fibrotest) Measures 5 markers: a-2-macroglobulin, haptoglobin, apolipoprotein A1, bilirubin, and GGT; predicts liver fibrosis 
Hepascore Measures 4 markers: α-2-macroglobulin, hyaluronic acid, bilirubin, and GGT; predicts liver fibrosis 
NASH Fibrotest Measures fibrosis for MASH; can estimate amount of fat in liver 
Scans  
Fibroscan/elastography Detects noninvasively (by ultrasound or MRI) degree of liver stiffness and can estimate liver fat content 
Blood tests  
ALT, AST Measures hepatocyte damage and liver inflammation 
APRI Measures liver fibrosis based on AST/platelet count ratio 
FIB-4 Measures liver fibrosis based on (age × AST)/ (platelet × √ALT) 
Fibrosure (Fibrotest) Measures 5 markers: a-2-macroglobulin, haptoglobin, apolipoprotein A1, bilirubin, and GGT; predicts liver fibrosis 
Hepascore Measures 4 markers: α-2-macroglobulin, hyaluronic acid, bilirubin, and GGT; predicts liver fibrosis 
NASH Fibrotest Measures fibrosis for MASH; can estimate amount of fat in liver 
Scans  
Fibroscan/elastography Detects noninvasively (by ultrasound or MRI) degree of liver stiffness and can estimate liver fat content 

GGT, γ-glutamyltranspeptidase; MASH, metabolic dysfunction–associated steatohepatitis; MRI, magnetic resonance imaging; ; NASH, nonalcoholic steatohepatitis.

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