Clinical characteristics of surgical patients with MPN at diagnosis
| Variable . | All (N = 184) . | PV (n = 87 [47%]) . | ET (n = 66 [36%]) . | MF (n = 31 [17%]) . | P value . |
|---|---|---|---|---|---|
| Age at diagnosis, median (range), y | 64 (19-89) | 65 (37-89) | 62 (19-85) | 58 (28-89) | .1 |
| Males, n (%) | 87 (48) | 40 (47) | 29 (45) | 18 (62) | .3 |
| Driver mutation, n (%) | |||||
| JAK2 | 151 (82) | 85 (98) | 43 (65) | 23 (74) | |
| CALR | 21 (11) | 18 (27) | 3 (10) | ||
| MPL | 6 (3) | 2 (3) | 4 (13) | ||
| Triple negative | 6 (3) | 3 (5) | 1 (3) | ||
| Cardiovascular risk factors∗ , n (%); N evaluable = 180 (98%) | .7 | ||||
| 0-1 | 111 (62) | 52 (60) | 39 (60) | 20 (69) | |
| 2+ | 69 (38) | 34 (40) | 26 (40) | 9 (31) | |
| Arterial thrombosis before or at diagnosis, n (%) | 32 (19) | 17 (22) | 12 (18) | 3 (10) | .1 |
| Venous thrombosis before or at diagnosis, n (%) | 11 (8) | 7 (13) | 4 (6) | 0 | .04 |
| Variable . | All (N = 184) . | PV (n = 87 [47%]) . | ET (n = 66 [36%]) . | MF (n = 31 [17%]) . | P value . |
|---|---|---|---|---|---|
| Age at diagnosis, median (range), y | 64 (19-89) | 65 (37-89) | 62 (19-85) | 58 (28-89) | .1 |
| Males, n (%) | 87 (48) | 40 (47) | 29 (45) | 18 (62) | .3 |
| Driver mutation, n (%) | |||||
| JAK2 | 151 (82) | 85 (98) | 43 (65) | 23 (74) | |
| CALR | 21 (11) | 18 (27) | 3 (10) | ||
| MPL | 6 (3) | 2 (3) | 4 (13) | ||
| Triple negative | 6 (3) | 3 (5) | 1 (3) | ||
| Cardiovascular risk factors∗ , n (%); N evaluable = 180 (98%) | .7 | ||||
| 0-1 | 111 (62) | 52 (60) | 39 (60) | 20 (69) | |
| 2+ | 69 (38) | 34 (40) | 26 (40) | 9 (31) | |
| Arterial thrombosis before or at diagnosis, n (%) | 32 (19) | 17 (22) | 12 (18) | 3 (10) | .1 |
| Venous thrombosis before or at diagnosis, n (%) | 11 (8) | 7 (13) | 4 (6) | 0 | .04 |
CALR, calreticulin; JAK2, Janus kinase 2; MPL, myeloproliferative leukemia virus oncogene.
Cardiovascular risk factors defined as: arterial hypertension, hyperlipidemia, diabetes requiring treatment, and active smoking. P values in bold are statistically significant.