Pertinent laboratory data following CART infusion
| Variable . | Patient 1 . | Patient 2 . | Patient 3 . | Patient 4 . | Patient 5 . |
|---|---|---|---|---|---|
| Day after infusion | D24 | D28 | D10 | D15 | D38 |
| CSF WBC (cells/uL) | 0 | 68 | 3 | 3 | 2 |
| CSF blasts, % | 0 | 95 | 0 | 0 | 0 |
| CSF protein (mg/dL) | N/A | 56 | 164 | 307 | 27 |
| CSF BH4 (nmol/L) | N/A | N/A | N/A | N/A | <5 |
| CSF qPCR at day 28, copies/μg DNA | 26 562 | 10 237 | 22 853 | N/A | 88 040 |
| Peripheral WBC at time of LP (k/μL) | 0.2 | 0.1 | 4.7 | 1.8 | 0.3 |
| Highest serum CART qPCR, copies/μg DNA | 82 198 (D28) | 412 318 (D28) | 113 502 (D7) | N/A | 136 002 (D10) |
| Serum B12, pg/mL (normal range) | 406 (247-1174) | 3022 (214-865) | 1396 (214-865) | 549 (264-1216) | N/A |
| Serum copper (normal range) (ug/dL) | N/A | N/A | 82.1 (57-129) | 122 (75-153) | N/A |
| Serum zinc (nornal range) (ug/dL) | N/A | N/A | 98.5 (60-120) | 116 (60-120) | N/A |
| Variable . | Patient 1 . | Patient 2 . | Patient 3 . | Patient 4 . | Patient 5 . |
|---|---|---|---|---|---|
| Day after infusion | D24 | D28 | D10 | D15 | D38 |
| CSF WBC (cells/uL) | 0 | 68 | 3 | 3 | 2 |
| CSF blasts, % | 0 | 95 | 0 | 0 | 0 |
| CSF protein (mg/dL) | N/A | 56 | 164 | 307 | 27 |
| CSF BH4 (nmol/L) | N/A | N/A | N/A | N/A | <5 |
| CSF qPCR at day 28, copies/μg DNA | 26 562 | 10 237 | 22 853 | N/A | 88 040 |
| Peripheral WBC at time of LP (k/μL) | 0.2 | 0.1 | 4.7 | 1.8 | 0.3 |
| Highest serum CART qPCR, copies/μg DNA | 82 198 (D28) | 412 318 (D28) | 113 502 (D7) | N/A | 136 002 (D10) |
| Serum B12, pg/mL (normal range) | 406 (247-1174) | 3022 (214-865) | 1396 (214-865) | 549 (264-1216) | N/A |
| Serum copper (normal range) (ug/dL) | N/A | N/A | 82.1 (57-129) | 122 (75-153) | N/A |
| Serum zinc (nornal range) (ug/dL) | N/A | N/A | 98.5 (60-120) | 116 (60-120) | N/A |
BH4, tetrahydrobiopterin; N/A, not available; qPCR, quantitative PCR.