Multivariable analysis of impact of race/ethnicity and SES on HCT outcomes after diagnosis of aGVHD, with aGVHD severity considered as a covariate
| Outcomes . | OS∗ . | TRM† . | Relapse‡ . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| n . | HR (95% CI) . | P value . | n . | HR (95% CI) . | P value . | n . | HR (95% CI) . | P value . | |
| Race/ethnicity | |||||||||
| Non-Hispanic White | 4513 | 1.00 | .1131§ | 4489 | 1.00 | .0392§ | 4513 | 1.00 | .4970§ |
| Non-Hispanic Black | 355 | 1.16 (1.0-1.35) | .0459 | 355 | 1.24 (0.98-1.56) | .0698 | 354 | 0.95 (0.80-1.14) | .5770 |
| Hispanic | 497 | 1.13 (0.98-1.29) | .0869 | 493 | 1.15 (0.98-1.36) | .0866 | 497 | 1.04 (0.88-1.23) | .6490 |
| Asian | 238 | 0.95 (0.81-1.11) | .5302 | 236 | 0.79 (0.61-1.02) | .0688 | 237 | 1.14 (0.94-1.39) | .1726 |
| SES | |||||||||
| <$48 000 | 1424 | 1.00 | .0339§ | 1416 | 1.00 | .0224§ | 1423 | 1.00 | .0013§ |
| $48 000-$60 999 | 1345 | 0.95 (0.85-1.06) | .3567 | 1339 | 1.01 (0.86-1.18) | .9187 | 1344 | 0.8 (0.70-0.91) | .0011 |
| $61 000-$79 999 | 1468 | 0.95 (0.85-1.06) | .3503 | 1463 | 0.98 (0.87-1.10) | .7484 | 1468 | 0.85 (0.75-0.96) | .0091 |
| ≥$80 000 | 1366 | 0.84 (0.75-0.95) | .0048 | 1355 | 0.86 (0.75-0.98) | .0242 | 1366 | 0.80 (0.71-0.92) | .0011 |
| Outcomes . | OS∗ . | TRM† . | Relapse‡ . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| n . | HR (95% CI) . | P value . | n . | HR (95% CI) . | P value . | n . | HR (95% CI) . | P value . | |
| Race/ethnicity | |||||||||
| Non-Hispanic White | 4513 | 1.00 | .1131§ | 4489 | 1.00 | .0392§ | 4513 | 1.00 | .4970§ |
| Non-Hispanic Black | 355 | 1.16 (1.0-1.35) | .0459 | 355 | 1.24 (0.98-1.56) | .0698 | 354 | 0.95 (0.80-1.14) | .5770 |
| Hispanic | 497 | 1.13 (0.98-1.29) | .0869 | 493 | 1.15 (0.98-1.36) | .0866 | 497 | 1.04 (0.88-1.23) | .6490 |
| Asian | 238 | 0.95 (0.81-1.11) | .5302 | 236 | 0.79 (0.61-1.02) | .0688 | 237 | 1.14 (0.94-1.39) | .1726 |
| SES | |||||||||
| <$48 000 | 1424 | 1.00 | .0339§ | 1416 | 1.00 | .0224§ | 1423 | 1.00 | .0013§ |
| $48 000-$60 999 | 1345 | 0.95 (0.85-1.06) | .3567 | 1339 | 1.01 (0.86-1.18) | .9187 | 1344 | 0.8 (0.70-0.91) | .0011 |
| $61 000-$79 999 | 1468 | 0.95 (0.85-1.06) | .3503 | 1463 | 0.98 (0.87-1.10) | .7484 | 1468 | 0.85 (0.75-0.96) | .0091 |
| ≥$80 000 | 1366 | 0.84 (0.75-0.95) | .0048 | 1355 | 0.86 (0.75-0.98) | .0242 | 1366 | 0.80 (0.71-0.92) | .0011 |
Other variable associated with OS included aGVHD grade, recipient age, refined disease risk index, hematopoietic cell transplant comorbidity index, and year of transplant.
Other variables associated with transplant-related mortality include aGVHD grade, recipient age, donor/recipient sex match, GVHD prophylaxis, hematopoietic cell transplant comorbidity index, and year of transplant.
Other variables associated with relapse include refined disease risk index, KPS, and total body irradiation dose.
Overall P value. A P value <.01 is considered statistically significant.