Baseline characteristics by patients with and without aneurysms
| . | Patients without aneurysm (n = 128) . | Patients with aneurysm (n = 27) . | P value . |
|---|---|---|---|
| Age, y | 21 (11, 28) | 30 (20, 37) | .003 |
| Female, n (%) | 70 (55%) | 18 (67%) | .25 |
| SCD type | .37 | ||
| HbS β+ thalassemia | 3 (2%) | 1 (4%) | |
| HbS β0 thalassemia | 9 (7%) | 4 (15%) | |
| HbSC | 15 (12%) | 1 (4%) | |
| HbSS | 101 (79%) | 22 (78%) | |
| Hb, g/dL | 8.9 (7.9, 10) | 8.3 (7.5, 9.3) | .07 |
| HbA, % | 0 (0, 29.3) | 0 (0, 28.3) | .96 |
| HbS, % | 71 (51, 83) | 77 (51, 83) | .32 |
| Hydroxyurea, n (%) | 49 (37%) | 11 (41%) | .83 |
| Exchange transfusion, n (%) | 31 (24%) | 4 (15%) | .29 |
| Hypertension | 14 (11%) | 3 (11%) | 1.00 |
| Diabetes mellitus | 4 (3%) | 0 (0%) | .35 |
| Current smoker∗ | 11 (9%) | 3 (16%) | .40 |
| SCI, n (%) | 77 (60%) | 17 (63%) | .79 |
| Overt stroke, n (%)† | 20 (16%) | 4 (15%) | .91 |
| Concurrent cerebral arterial stenosis of ≥50% or occlusion | 16 (13%) | 6 (22%) | .24 |
| Number of aneurysms per patient | - | ||
| 1 | 20 (74%) | ||
| 2 | 4 (15%) | ||
| ≥3 | 3 (11%) | ||
| By aneurysm (n = 43) | - | ||
| Size (mm), n (%) | |||
| <2 | 3 (7%) | ||
| 2-3 | 32 (74%) | ||
| 4-5 | 5 (12%) | ||
| ≥6 | 3 (7%) | ||
| Location, n (%) | |||
| Internal carotid artery | 17 (40%) | ||
| Ophthalmic artery | 6 (14%) | ||
| Anterior communicating artery | 5 (12%) | ||
| Posterior communicating artery | 4 (9%) | ||
| Posterior cerebral artery | 3 (7%) | ||
| Basilar artery | 3 (7%) | ||
| Middle cerebral artery | 2 (5%) | ||
| Vertebral artery | 2 (5%) | ||
| Anterior cerebral artery | 1 (2%) | ||
| Laterality, n (%) | |||
| Left hemisphere | 21 (50%) | ||
| Right hemisphere | 14 (32%) | ||
| Midline | 8 (18%) |
| . | Patients without aneurysm (n = 128) . | Patients with aneurysm (n = 27) . | P value . |
|---|---|---|---|
| Age, y | 21 (11, 28) | 30 (20, 37) | .003 |
| Female, n (%) | 70 (55%) | 18 (67%) | .25 |
| SCD type | .37 | ||
| HbS β+ thalassemia | 3 (2%) | 1 (4%) | |
| HbS β0 thalassemia | 9 (7%) | 4 (15%) | |
| HbSC | 15 (12%) | 1 (4%) | |
| HbSS | 101 (79%) | 22 (78%) | |
| Hb, g/dL | 8.9 (7.9, 10) | 8.3 (7.5, 9.3) | .07 |
| HbA, % | 0 (0, 29.3) | 0 (0, 28.3) | .96 |
| HbS, % | 71 (51, 83) | 77 (51, 83) | .32 |
| Hydroxyurea, n (%) | 49 (37%) | 11 (41%) | .83 |
| Exchange transfusion, n (%) | 31 (24%) | 4 (15%) | .29 |
| Hypertension | 14 (11%) | 3 (11%) | 1.00 |
| Diabetes mellitus | 4 (3%) | 0 (0%) | .35 |
| Current smoker∗ | 11 (9%) | 3 (16%) | .40 |
| SCI, n (%) | 77 (60%) | 17 (63%) | .79 |
| Overt stroke, n (%)† | 20 (16%) | 4 (15%) | .91 |
| Concurrent cerebral arterial stenosis of ≥50% or occlusion | 16 (13%) | 6 (22%) | .24 |
| Number of aneurysms per patient | - | ||
| 1 | 20 (74%) | ||
| 2 | 4 (15%) | ||
| ≥3 | 3 (11%) | ||
| By aneurysm (n = 43) | - | ||
| Size (mm), n (%) | |||
| <2 | 3 (7%) | ||
| 2-3 | 32 (74%) | ||
| 4-5 | 5 (12%) | ||
| ≥6 | 3 (7%) | ||
| Location, n (%) | |||
| Internal carotid artery | 17 (40%) | ||
| Ophthalmic artery | 6 (14%) | ||
| Anterior communicating artery | 5 (12%) | ||
| Posterior communicating artery | 4 (9%) | ||
| Posterior cerebral artery | 3 (7%) | ||
| Basilar artery | 3 (7%) | ||
| Middle cerebral artery | 2 (5%) | ||
| Vertebral artery | 2 (5%) | ||
| Anterior cerebral artery | 1 (2%) | ||
| Laterality, n (%) | |||
| Left hemisphere | 21 (50%) | ||
| Right hemisphere | 14 (32%) | ||
| Midline | 8 (18%) |
Smoking history missing in 11 and 8 patients without and with aneurysms, respectively.
Before study enrollment, 2 patients without aneurysms had a history of intracranial hemorrhage due to arteriovenous malformation and traumatic brain injury. All other patients with overt strokes experienced ischemic strokes.