Table 3. CBS SD and MADRS scores for... | American Society of Hematology

Table 3.

CBS SD and MADRS scores for patients with CM-TMA

Visit	Patient 1		Patient 2		Patient 3		Patient 4		Patient 5		Patient 6		Patient 7
Visit	1	2	1	2	1	2	1	2	1	2	1	2	1	2
CBS cognitive test
Reasoning
Odd 1 out	−0.96	−0.21	−0.52	NA	−0.27	0.66	0.67	0.42	−0.50	NA	1.36	0.20	−1.20	−2.20∗
Polygons	−0.36	−1.46	−1.44	NA	−1.16	−0.36	−0.23	−0.94	−0.41	−1.39	−1.43	0.43	−1.19	−0.51
Spatial planning	−0.39	−0.49	−1.23	NA	−0.43	1.19	0.45	−0.18	0.52	−0.10	−0.08	0.43	−1.57	−1.08
Rotations	−0.99	0.43	−1.95	NA	NA	0.27	−0.65	−0.09	−1.72	−1.20	−1.22	−1.72	−1.84	−0.64
Short-term memory
Spatial span	−1.04	−1.05	−1.10	NA	0.47	0.47	−1.92	−0.91	−1.15	−1.15	0.47	1.54	−1.05	−1.05
Monkey ladder	−0.69	−0.69	−1.62	NA	−0.33	−0.33	−1.46	−1.46	0.99	0.99	0.58	−0.33	−1.60	−0.69
Token search	−0.51	−0.99	−2.21∗	NA	0.90	0.41	0.12	−0.78	−1.42	0.15	−1.55	−0.57	0.93	0.45
Pair associates	−1.39	−1.39	−0.21	NA	0.72	0.72	2.49	−1.04	1.17	−0.55	0.72	2.49	0.33	2.05
Verbal memory
Grammatical reasoning	−0.44	−0.25	−1.06	NA	0.07	−0.71	0.02	−0.19	−0.38	−0.61	−2.67∗	−1.89	−1.38	−0.06
Digit span	−0.77	−1.46	−1.29	NA	−0.66	−1.33	−0.19	−0.19	0.77	−1.22	−1.33	−1.33	−1.46	−0.77
Concentration
Feature match	−1.15	−2.28∗	−0.95	NA	−0.42	−1.11	−2.27∗	−1.41	−0.54	−2.73∗	0.10	−0.14	−1.08	−0.05
Double trouble	0.13	−1.55	−1.16	NA	0.12	0.69	−0.45	−0.73	NA	−0.32	−0.95	−1.58	0.27	−0.08
MADRS score
Total	7	16	8	NA	25	12	5	3	4	6	2	1	5	8

Visit	Patient 1		Patient 2		Patient 3		Patient 4		Patient 5		Patient 6		Patient 7
Visit	1	2	1	2	1	2	1	2	1	2	1	2	1	2
CBS cognitive test
Reasoning
Odd 1 out	−0.96	−0.21	−0.52	NA	−0.27	0.66	0.67	0.42	−0.50	NA	1.36	0.20	−1.20	−2.20∗
Polygons	−0.36	−1.46	−1.44	NA	−1.16	−0.36	−0.23	−0.94	−0.41	−1.39	−1.43	0.43	−1.19	−0.51
Spatial planning	−0.39	−0.49	−1.23	NA	−0.43	1.19	0.45	−0.18	0.52	−0.10	−0.08	0.43	−1.57	−1.08
Rotations	−0.99	0.43	−1.95	NA	NA	0.27	−0.65	−0.09	−1.72	−1.20	−1.22	−1.72	−1.84	−0.64
Short-term memory
Spatial span	−1.04	−1.05	−1.10	NA	0.47	0.47	−1.92	−0.91	−1.15	−1.15	0.47	1.54	−1.05	−1.05
Monkey ladder	−0.69	−0.69	−1.62	NA	−0.33	−0.33	−1.46	−1.46	0.99	0.99	0.58	−0.33	−1.60	−0.69
Token search	−0.51	−0.99	−2.21∗	NA	0.90	0.41	0.12	−0.78	−1.42	0.15	−1.55	−0.57	0.93	0.45
Pair associates	−1.39	−1.39	−0.21	NA	0.72	0.72	2.49	−1.04	1.17	−0.55	0.72	2.49	0.33	2.05
Verbal memory
Grammatical reasoning	−0.44	−0.25	−1.06	NA	0.07	−0.71	0.02	−0.19	−0.38	−0.61	−2.67∗	−1.89	−1.38	−0.06
Digit span	−0.77	−1.46	−1.29	NA	−0.66	−1.33	−0.19	−0.19	0.77	−1.22	−1.33	−1.33	−1.46	−0.77
Concentration
Feature match	−1.15	−2.28∗	−0.95	NA	−0.42	−1.11	−2.27∗	−1.41	−0.54	−2.73∗	0.10	−0.14	−1.08	−0.05
Double trouble	0.13	−1.55	−1.16	NA	0.12	0.69	−0.45	−0.73	NA	−0.32	−0.95	−1.58	0.27	−0.08
MADRS score
Total	7	16	8	NA	25	12	5	3	4	6	2	1	5	8

Visit 1 occurred at the time of the initial study visit (month 0), and visit 2 occurred 12 months afterward unless data were unavailable for that time. This applies to patient 1’s MADRS score at visit 1, which was done at month 6, and patient 6’s MADRS and CBS scores at visit 2, which were done at month 6. The numbers under the CBS section of the chart indicate SD from age- and sex-matched controls. Under the MADRS section of the chart, total score of 0 to 6 denotes no depression; 7 to 19, mild depression; 20 to 34, moderate depression; and >34, severe depression.

NA indicates not applicable; in these cases, either patient data were missing or the score was interpreted to be due to patient error.

∗

Scores >2 SDs below the mean.

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