Summary of findings of standard-of-care MRI in patients with CM-TMA
| . | Month 0 . | Month 12 . | ||
|---|---|---|---|---|
| White matter hyperintensities . | Other radiologic findings . | White matter hyperintensities . | Other radiologic findings . | |
| Patient 1 | Spots (5) | None | Spots (2) | None |
| Patient 2 | Spots (≥30) | Atrophy | NA | NA |
| Patient 3 | Spots (5) | Chronic lacunar infarcts (2) | Spots (6) | Unusual spot in midbrain, 1.1 cm pineal cyst, chronic lacunar infarct (1) |
| Patient 4 | Spots (30-40) | Atrophy, aneurysm (1 mm) | Spots (≥20) | Global atrophy, blood products, chronic lacunar infarct (1) |
| Patient 5 | Spots (10) | Mild supratentorial volume loss, bilateral lacunar infarcts (basal ganglia) | Spots (12) | Mild supratentorial volume loss, bilateral lacunar infarcts (basal ganglia) |
| Patient 6 | Spots (≥20) | Chronic lacunar infarcts (3-4) | Spots (≥20) | Chronic lacunar infarcts (3-4) |
| Patient 7 | Spots (3) | None | Spot (1) | None |
| . | Month 0 . | Month 12 . | ||
|---|---|---|---|---|
| White matter hyperintensities . | Other radiologic findings . | White matter hyperintensities . | Other radiologic findings . | |
| Patient 1 | Spots (5) | None | Spots (2) | None |
| Patient 2 | Spots (≥30) | Atrophy | NA | NA |
| Patient 3 | Spots (5) | Chronic lacunar infarcts (2) | Spots (6) | Unusual spot in midbrain, 1.1 cm pineal cyst, chronic lacunar infarct (1) |
| Patient 4 | Spots (30-40) | Atrophy, aneurysm (1 mm) | Spots (≥20) | Global atrophy, blood products, chronic lacunar infarct (1) |
| Patient 5 | Spots (10) | Mild supratentorial volume loss, bilateral lacunar infarcts (basal ganglia) | Spots (12) | Mild supratentorial volume loss, bilateral lacunar infarcts (basal ganglia) |
| Patient 6 | Spots (≥20) | Chronic lacunar infarcts (3-4) | Spots (≥20) | Chronic lacunar infarcts (3-4) |
| Patient 7 | Spots (3) | None | Spot (1) | None |
Lesions were qualitative and mostly located in the frontal lobe and in the periventricular area. Spots are small nonspecific areas of white matter hyperintensity measuring 2 to 15 mm. Chronic lacunar infarcts are regions of necrosis typically measuring 2 to 15 mm.
NA indicates that results are not available.