Multivariate models of EFS and TRM
| Characteristic∗ . | 4-y EFS . | 4-y CI of TRM . | ||
|---|---|---|---|---|
| HR (95% CI) . | P value† . | HR (95% CI) . | P value† . | |
| Sex, male vs female | 2.08 (0.95-4.54) | .053 | 0.90 (0.34-2.38) | .822 |
| Age, ≥10 y vs <10 y | 0.71 (0.32-1.60) | .383 | 1.29 (0.49-3.37) | .569 |
| Era, 2000-2009 vs 1985-1999 | 0.83 (0.16-4.24) | .798 | 0.91 (0.16-5.09) | .906 |
| Era, 2010-2023 vs 1985-1999 | 1.19 (0.26-5.51) | .797 | 0.39 (0.08-2.03) | .199 |
| Respiratory category, 3 vs 1+2‡ | 0.40 (0.12-1.33) | .098 | 2.86 (0.98-8.36) | .035 |
| ATM PV, absent vs residual | 0.36 (0.16-0.82) | .009 | 14.11 (1.36-146.31) | .029 |
| Characteristic∗ . | 4-y EFS . | 4-y CI of TRM . | ||
|---|---|---|---|---|
| HR (95% CI) . | P value† . | HR (95% CI) . | P value† . | |
| Sex, male vs female | 2.08 (0.95-4.54) | .053 | 0.90 (0.34-2.38) | .822 |
| Age, ≥10 y vs <10 y | 0.71 (0.32-1.60) | .383 | 1.29 (0.49-3.37) | .569 |
| Era, 2000-2009 vs 1985-1999 | 0.83 (0.16-4.24) | .798 | 0.91 (0.16-5.09) | .906 |
| Era, 2010-2023 vs 1985-1999 | 1.19 (0.26-5.51) | .797 | 0.39 (0.08-2.03) | .199 |
| Respiratory category, 3 vs 1+2‡ | 0.40 (0.12-1.33) | .098 | 2.86 (0.98-8.36) | .035 |
| ATM PV, absent vs residual | 0.36 (0.16-0.82) | .009 | 14.11 (1.36-146.31) | .029 |
The model includes 96 treated patients with available data on ATM PV class.
Patients with “other” tumor types were excluded.
To avoid multicollinearity, in models that included ATM PV class, we did not include tumor type and neurological status, which were highly associated with ATM PV class (Fisher test P values <.001 and .009, respectively).
P values are based on a comparison performed at a predefined time point of 4 years from cancer diagnosis on the basis of log-log transformation
Respiratory status: (1) asymptomatic; (2) recurrent respiratory exacerbations/infections (≥3 per year); and (3) chronic bronchitis/ bronchiectasis.