Table 1. Key model inputs Parameter .... | American Society of Hematology

Table 1.

Key model inputs

Parameter	Value	Range considered in sensitivity analysis	Original model inputs∗	References
Percentage of patients with severe phenotype	35%	20%-60%	25% (10%-40%)	8,9
Baseline annual expenditure for patient with SCD†	$51 700	$21 830-$85 680	$48 900 ($19 900-$78 100)	¹³,¹⁴
Cost of single gene therapy treatment per person (million)	$2.29	$1.78-$3.19	$2.267 ($1.769-$2.659)	7,11,12
Annual market diffusion rate for gene therapy	7%	2%-15%	7% (2%-15%)	Assumed

Parameter	Value	Range considered in sensitivity analysis	Original model inputs∗	References
Percentage of patients with severe phenotype	35%	20%-60%	25% (10%-40%)	8,9
Baseline annual expenditure for patient with SCD†	$51 700	$21 830-$85 680	$48 900 ($19 900-$78 100)	¹³,¹⁴
Cost of single gene therapy treatment per person (million)	$2.29	$1.78-$3.19	$2.267 ($1.769-$2.659)	7,11,12
Annual market diffusion rate for gene therapy	7%	2%-15%	7% (2%-15%)	Assumed

Costs adjusted from 2019 to 2024 US dollars.

Average of estimates in associated reference and adjusted to 2024 US dollars.