Multivariable Cox regression models assessing predictors of OS in different indolent lymphoma subtypes
| . | FL (n = 23 384) . | SMZL (n = 2005) . | NMZL (n = 6374) . | EMZL (n = 12 151) . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR . | 95% CI . | P value . | HR . | 95% CI . | P value . | HR . | 95% CI . | P value . | HR . | 95% CI . | P value . | |
| Age (y) | ||||||||||||
| ≥60 vs <60 | 3.67 | 3.47-3.87 | <.001 | 3.09 | 2.56-3.73 | <.001 | 3.85 | 3.45-4.29 | <.001 | 5.58 | 5.07-6.13 | <.001 |
| Gender | ||||||||||||
| Male vs female | 1.25 | 1.19-1.31 | <.001 | 1.14 | 0.99-1.32 | .07 | 1.20 | 1.10- 1.30 | <.001 | 1.23 | 1.15-1.31 | <.001 |
| Ann Arbor stage | ||||||||||||
| III-IV vs I-II | 1.25 | 1.19-1.31 | <.001 | 1.17 | 0.99-1.38 | .07 | 1.34 | 1.22-1.46 | <.001 | 1.49 | 1.38-1.60 | <.001 |
| HGT† | ||||||||||||
| Yes vs no | 4.22 | 3.83-4.65 | <.001 | 4.01 | 3.07-5.24 | <.001 | 3.74 | 3.08-4.54 | <.001 | 4.39 | 3.61-5.34 | <.001 |
| Management | ||||||||||||
| Observation vs treatment | 0.95 | 0.90-0.99 | .03 | 0.84 | 0.72-0.98 | .03 | 0.94 | 0.87-1.02 | .15 | 1.09 | 1.02-1.16 | .01 |
| . | FL (n = 23 384) . | SMZL (n = 2005) . | NMZL (n = 6374) . | EMZL (n = 12 151) . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR . | 95% CI . | P value . | HR . | 95% CI . | P value . | HR . | 95% CI . | P value . | HR . | 95% CI . | P value . | |
| Age (y) | ||||||||||||
| ≥60 vs <60 | 3.67 | 3.47-3.87 | <.001 | 3.09 | 2.56-3.73 | <.001 | 3.85 | 3.45-4.29 | <.001 | 5.58 | 5.07-6.13 | <.001 |
| Gender | ||||||||||||
| Male vs female | 1.25 | 1.19-1.31 | <.001 | 1.14 | 0.99-1.32 | .07 | 1.20 | 1.10- 1.30 | <.001 | 1.23 | 1.15-1.31 | <.001 |
| Ann Arbor stage | ||||||||||||
| III-IV vs I-II | 1.25 | 1.19-1.31 | <.001 | 1.17 | 0.99-1.38 | .07 | 1.34 | 1.22-1.46 | <.001 | 1.49 | 1.38-1.60 | <.001 |
| HGT† | ||||||||||||
| Yes vs no | 4.22 | 3.83-4.65 | <.001 | 4.01 | 3.07-5.24 | <.001 | 3.74 | 3.08-4.54 | <.001 | 4.39 | 3.61-5.34 | <.001 |
| Management | ||||||||||||
| Observation vs treatment | 0.95 | 0.90-0.99 | .03 | 0.84 | 0.72-0.98 | .03 | 0.94 | 0.87-1.02 | .15 | 1.09 | 1.02-1.16 | .01 |
FL grade 1 to 2.
Time-dependent variable.