Multivariable analysis of transplants outcomes
| Variable . | aGVHD 2-4 . | aGVHD 3-4 . | cGVHD . | Ext cGVHD . | NRM . | Relapse . | OS . | PFS . | GRFS . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | |
| GVHD prophylaxis | ||||||||||||||||||
| CNI based | 1 | .1 | 1 | .15 | 1 | <.001 | 1 | .004 | 1 | .06 | 1 | .03 | 1 | .005 | 1 | .005 | 1 | <.001 |
| PTCy | 0.71 (0.5-1.1) | 0.64 (0.3-1.2) | 0.46 (0.3-0.7) | 0.4 (0.2-0.8) | 0.54 (0.3-1) | 0.58 (0.3-0.9) | 0.57 (0.4-0.8) | 0.57 (0.4-0.8) | 0.53 (0.4-0.7) | |||||||||
| Type of donor | ||||||||||||||||||
| MSD | 1 | .06 | 1 | .73 | 1 | .38 | 1 | .25 | 1 | .37 | 1 | .004 | 1 | .43 | 1 | .09 | 1 | .07 |
| MUD | 1.5 (1-2.2) | 1.11 (0.6-2.1) | 0.83 (0.5-1.2) | 0.7 (0.4-1.2) | 1.31 (0.7-2.4) | 0.42 (0.2-0.7) | 1.21 (0.8-1.9) | 0.71 (0.5-1.1) | 0.75 (0.6-1) | |||||||||
| Patient age by 10 y | 1.05 (0.9-1.2) | .52 | 1.03 (0.8-1.3) | .82 | 1.11 (0.9-1.3) | .23 | 1.15 (0.9-1.4) | .21 | 1.53 (1.2-1.9) | <.001 | 0.8 (0.7-1) | .09 | 1.43 (1.2-1.7) | <.001 | 1.07 (0.9-1.2) | .37 | 1.08 (1-1.22) | .21 |
| Karnofsky | ||||||||||||||||||
| ≤90 | 1 | .63 | 1 | .59 | 1 | .3 | 1 | .99 | 1 | .56 | 1 | .06 | 1 | .91 | 1 | .07 | 1 | .45 |
| >90 | 0.9 (0.6-1.4) | 1.23 (0.6-2.6) | 0.78 (0.5-1.2) | 1 (0.5-1.9) | 0.81 (0.4-1.6) | 0.61 (0.4-1) | 0.97 (0.5-1.7) | 0.68 (0.4-1) | 0.88 (0.6-1.2) | |||||||||
| Disease status at HSCT | ||||||||||||||||||
| Chemosensitive | 1 | .61 | 1 | .84 | 1 | .5 | 1 | .41 | 1 | .36 | 1 | <.001 | 1 | .007 | 1 | <.001 | 1 | <.001 |
| Refractory | 1.1 (0.7-1.9) | 0.92 (0.4-2) | 0.82 (0.4-1.4) | 1.3 (0.7-2.5) | 1.4 (0.7-2.9) | 2.36 (1.4-3.9) | 2.01 (1.2-3.4) | 1.96 (1.3-2.9) | 1.95 (1.4-2.7) | |||||||||
| Conditioning intensity | ||||||||||||||||||
| RIC | 1 | .1 | 1 | .8 | 1 | .11 | 1 | .04 | 1 | .16 | 1 | .51 | 1 | .62 | 1 | .78 | 1 | .14 |
| MAC | 0.7 (0.4-1.07) | 0.92 (0.5-1.7) | 0.7 (0.5-1.1) | 0.51 (0.2-0.9) | 0.57 (0.3-1.2) | 1.2 (0.7-1.9) | 0.88 (0.5-1.4) | 0.95 (0.6-1.4) | 0.79 (0.6-1) | |||||||||
| Variable . | aGVHD 2-4 . | aGVHD 3-4 . | cGVHD . | Ext cGVHD . | NRM . | Relapse . | OS . | PFS . | GRFS . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | |
| GVHD prophylaxis | ||||||||||||||||||
| CNI based | 1 | .1 | 1 | .15 | 1 | <.001 | 1 | .004 | 1 | .06 | 1 | .03 | 1 | .005 | 1 | .005 | 1 | <.001 |
| PTCy | 0.71 (0.5-1.1) | 0.64 (0.3-1.2) | 0.46 (0.3-0.7) | 0.4 (0.2-0.8) | 0.54 (0.3-1) | 0.58 (0.3-0.9) | 0.57 (0.4-0.8) | 0.57 (0.4-0.8) | 0.53 (0.4-0.7) | |||||||||
| Type of donor | ||||||||||||||||||
| MSD | 1 | .06 | 1 | .73 | 1 | .38 | 1 | .25 | 1 | .37 | 1 | .004 | 1 | .43 | 1 | .09 | 1 | .07 |
| MUD | 1.5 (1-2.2) | 1.11 (0.6-2.1) | 0.83 (0.5-1.2) | 0.7 (0.4-1.2) | 1.31 (0.7-2.4) | 0.42 (0.2-0.7) | 1.21 (0.8-1.9) | 0.71 (0.5-1.1) | 0.75 (0.6-1) | |||||||||
| Patient age by 10 y | 1.05 (0.9-1.2) | .52 | 1.03 (0.8-1.3) | .82 | 1.11 (0.9-1.3) | .23 | 1.15 (0.9-1.4) | .21 | 1.53 (1.2-1.9) | <.001 | 0.8 (0.7-1) | .09 | 1.43 (1.2-1.7) | <.001 | 1.07 (0.9-1.2) | .37 | 1.08 (1-1.22) | .21 |
| Karnofsky | ||||||||||||||||||
| ≤90 | 1 | .63 | 1 | .59 | 1 | .3 | 1 | .99 | 1 | .56 | 1 | .06 | 1 | .91 | 1 | .07 | 1 | .45 |
| >90 | 0.9 (0.6-1.4) | 1.23 (0.6-2.6) | 0.78 (0.5-1.2) | 1 (0.5-1.9) | 0.81 (0.4-1.6) | 0.61 (0.4-1) | 0.97 (0.5-1.7) | 0.68 (0.4-1) | 0.88 (0.6-1.2) | |||||||||
| Disease status at HSCT | ||||||||||||||||||
| Chemosensitive | 1 | .61 | 1 | .84 | 1 | .5 | 1 | .41 | 1 | .36 | 1 | <.001 | 1 | .007 | 1 | <.001 | 1 | <.001 |
| Refractory | 1.1 (0.7-1.9) | 0.92 (0.4-2) | 0.82 (0.4-1.4) | 1.3 (0.7-2.5) | 1.4 (0.7-2.9) | 2.36 (1.4-3.9) | 2.01 (1.2-3.4) | 1.96 (1.3-2.9) | 1.95 (1.4-2.7) | |||||||||
| Conditioning intensity | ||||||||||||||||||
| RIC | 1 | .1 | 1 | .8 | 1 | .11 | 1 | .04 | 1 | .16 | 1 | .51 | 1 | .62 | 1 | .78 | 1 | .14 |
| MAC | 0.7 (0.4-1.07) | 0.92 (0.5-1.7) | 0.7 (0.5-1.1) | 0.51 (0.2-0.9) | 0.57 (0.3-1.2) | 1.2 (0.7-1.9) | 0.88 (0.5-1.4) | 0.95 (0.6-1.4) | 0.79 (0.6-1) | |||||||||
aGVHD, acute graft-versus-host disease; Ext cGVHD, extensive chronic graft-versus-host disease; MAC, Myeloablative conditioning; RIC, Reduced-intensity conditioning; CI, confidence interval.
The boldface values considered statistically significant.