Multivariable Cox proportional hazard model for PFS in BCMA CAR-T cohort
| Variable . | HR . | 95 % CI . | P value . |
|---|---|---|---|
| Age at CAR-T infusion | 0.99 | 0.96-1.01 | .32 |
| ALCmax, >1 × 103/μL | |||
| ALCmax, ≤1.0 × 103 cells per μL | — | — | <.001 |
| ALCmax, >1.0 × 103 cells per μL | 0.35 | 0.19-0.61 | |
| EMD | |||
| No nonparaskeletal disease | — | — | .002 |
| Nonparaskeletal EMD | 2.2 | 1.3-3.6 | |
| CAR-T product received | |||
| Ide-cel | — | — | .43 |
| Cilta-cel | 0.8 | 0.47-1.39 | |
| Number of previous lines | 1.05 | 0.99-1.1 | .1 |
| High-risk CG∗ | |||
| No high-risk CG | — | — | .061 |
| High-risk CG | 1.63 | 0.98-2.7 | |
| Variable . | HR . | 95 % CI . | P value . |
|---|---|---|---|
| Age at CAR-T infusion | 0.99 | 0.96-1.01 | .32 |
| ALCmax, >1 × 103/μL | |||
| ALCmax, ≤1.0 × 103 cells per μL | — | — | <.001 |
| ALCmax, >1.0 × 103 cells per μL | 0.35 | 0.19-0.61 | |
| EMD | |||
| No nonparaskeletal disease | — | — | .002 |
| Nonparaskeletal EMD | 2.2 | 1.3-3.6 | |
| CAR-T product received | |||
| Ide-cel | — | — | .43 |
| Cilta-cel | 0.8 | 0.47-1.39 | |
| Number of previous lines | 1.05 | 0.99-1.1 | .1 |
| High-risk CG∗ | |||
| No high-risk CG | — | — | .061 |
| High-risk CG | 1.63 | 0.98-2.7 | |
Only patients with a follow-up >1 month were included. The bold characters emphasize the significant values associated with ALC max and for visualization purposes.
Presence of any of deletion 17p/t(4;14)/t(14;16)/gain 1q.