Baseline characteristics of 142 188 individuals from the general population according to study cohort
| . | Cohort . | ||
|---|---|---|---|
| Copenhagen City Heart Study . | Copenhagen General Population Study . | Danish General Suburban Population Study . | |
| Individuals, n | 13 661 | 108 061 | 20 466 |
| Plasma iron, n (%) | 8 884 (65)∗ | 107 343 (99) | 20 429 (100) |
| Plasma transferrin saturation, n (%) | 8 871 (65)∗ | 107 302 (99) | 20 426 (100) |
| Plasma ferritin, n (%) | 8 999 (66)∗ | 8 632 (8) | 20 389 (100) |
| Hemochromatosis genotyped, n (%) | 9 174 (67)∗ | 103 276 (96) | 20 092 (98) |
| Age (IQR), y | 61 (49-70) | 58 (48-67) | 57 (46-67) |
| Year of birth (IQR) | 1928 (1919-1940) | 1951 (1942-1961) | 1954 (1945-1966) |
| Men, n (%) | 6 438 (47) | 48 640 (45) | 9 344 (46) |
| Premenopausal women, n (% of women) | 2 527 (35) | 19 298 (32) | 3 962 (36) |
| Ever smokers, n (%) | 10 817 (79) | 62 463 (58) | 11 470 (56) |
| Cumulative smoking (IQR)†, pack-years | 22 (9-38) | 16 (6-30) | 18 (8-31) |
| Alcohol consumption >168/84 g per wk, n (%)‡ | 3 742 (27) | 42 232 (39) | 4 852 (24) |
| Body mass index (IQR), kg/m2 | 24.9 (22.5-27.8) | 25.6 (23.2-28.4) | 26.1 (23.5-29.2) |
| Any comorbidity, n (%)§ | 1 570 (11) | 23 209 (21) | 4 355 (21) |
| Plasma C-reactive protein (IQR), mg/L | 1.7 (1.3-3.0) | 1.4 (0.9-2.3) | 1.4 (0.7-3.0) |
| . | Cohort . | ||
|---|---|---|---|
| Copenhagen City Heart Study . | Copenhagen General Population Study . | Danish General Suburban Population Study . | |
| Individuals, n | 13 661 | 108 061 | 20 466 |
| Plasma iron, n (%) | 8 884 (65)∗ | 107 343 (99) | 20 429 (100) |
| Plasma transferrin saturation, n (%) | 8 871 (65)∗ | 107 302 (99) | 20 426 (100) |
| Plasma ferritin, n (%) | 8 999 (66)∗ | 8 632 (8) | 20 389 (100) |
| Hemochromatosis genotyped, n (%) | 9 174 (67)∗ | 103 276 (96) | 20 092 (98) |
| Age (IQR), y | 61 (49-70) | 58 (48-67) | 57 (46-67) |
| Year of birth (IQR) | 1928 (1919-1940) | 1951 (1942-1961) | 1954 (1945-1966) |
| Men, n (%) | 6 438 (47) | 48 640 (45) | 9 344 (46) |
| Premenopausal women, n (% of women) | 2 527 (35) | 19 298 (32) | 3 962 (36) |
| Ever smokers, n (%) | 10 817 (79) | 62 463 (58) | 11 470 (56) |
| Cumulative smoking (IQR)†, pack-years | 22 (9-38) | 16 (6-30) | 18 (8-31) |
| Alcohol consumption >168/84 g per wk, n (%)‡ | 3 742 (27) | 42 232 (39) | 4 852 (24) |
| Body mass index (IQR), kg/m2 | 24.9 (22.5-27.8) | 25.6 (23.2-28.4) | 26.1 (23.5-29.2) |
| Any comorbidity, n (%)§ | 1 570 (11) | 23 209 (21) | 4 355 (21) |
| Plasma C-reactive protein (IQR), mg/L | 1.7 (1.3-3.0) | 1.4 (0.9-2.3) | 1.4 (0.7-3.0) |
n (%) is displayed for categorical variables, whereas median (IQR) is displayed for continuous variables.
IQR, interquartile range.
In the Copenhagen City Heart Study, 8999 individuals were included from the 1981 to 1983 examination, and 9725 individuals were included from the 1991 to 1994 examination, of whom 5063 individuals attended both examinations. Only individuals who attended the 1991 to 1994 examination had iron (8884 individuals of 10 135 attending [88%]), transferrin saturation (8871 individuals of 10 135 attending [88%]), and hemochromatosis genotype (9174 individuals of 10 135 attending [91%]) measured. Only individuals who attended the 1981 to 1983 examination had ferritin measured (8999 individuals of 12 698 attending [71%]).
Ever smokers only.
>168 g/wk for men and >84 g/wk for women.
Any comorbidity as defined by the Charlson comorbidity index.