Table 1. Correlation of biomarkers with... | American Society of Hematology

Table 1.

Correlation of biomarkers with response and tumor burden by flow cytometry

Biomarker	Biomarker ∼ clinical response	Biomarker ∼ BMPCs, %
Biomarker	P value	Spearman correlation coefficient (Rs)	Spearman P value	Correlated with tumor burden
BM CD38⁺/CD4⁺ T cells, %	.004	0.203	.018	Y
PB PD-1⁺TIM-3⁺/T cells, %	.005	0.100	.226	N
PB CD38⁺/CD3⁺CD4⁺CD8⁻ T cells, %	.009	0.057	.486	N
PB CD45⁺CD3⁺, ×10⁶/L	.012	−0.106	.359	N
PB PD-1⁺/CD8⁺ T cells, %	.014	0.058	.483	N
BM CD38⁺/T cells, %	.014	0.207	.016	Y
PB TIM-3⁺/T cells, %	.017	0.033	.687	N
PB CD3⁺/CD45⁺ lymphocytes, %	.017	0.129	.271	N
PB PD-1⁺TIM-3⁺/CD8⁺ T cells, %	.018	0.129	.116	N
PB CD38⁺ Tregs, %	.019	0.004	.964	N
BM CD38⁺/CD8⁺ T cells, %	.020	0.276	.001	Y
PB CD45⁺CD3⁺CD8⁺, ×10⁶/L	.024	–0.135	.243	N
PB Tregs/CD4⁺ T cells, %	.029	0.164	.046	Y
BM PD-1⁺TIM-3⁺/CD4⁺ T cells, %	.029	0.149	.084	N
PB PD-1⁺/T cells, %	.032	0.016	.842	N
PB PD-1⁺TIM-3⁺/CD4⁺ T cells, %	.032	0.171	.037	Y
BM PD-1⁺TIM-3⁺/T cells, %	.033	0.135	.116	N
BM TIM-3⁺/CD8⁺ T cells, %	.041	−0.052	.547	N
BM PD-1⁺CD38⁺/CD3⁺CD8⁻CD4⁺ cells, %	.042	0.324	.001	Y
BM PD-1⁺CD38⁺/CD3⁺ cells, %	.044	0.279	.004	Y

Biomarker	Biomarker ∼ clinical response	Biomarker ∼ BMPCs, %
Biomarker	P value	Spearman correlation coefficient (Rs)	Spearman P value	Correlated with tumor burden
BM CD38⁺/CD4⁺ T cells, %	.004	0.203	.018	Y
PB PD-1⁺TIM-3⁺/T cells, %	.005	0.100	.226	N
PB CD38⁺/CD3⁺CD4⁺CD8⁻ T cells, %	.009	0.057	.486	N
PB CD45⁺CD3⁺, ×10⁶/L	.012	−0.106	.359	N
PB PD-1⁺/CD8⁺ T cells, %	.014	0.058	.483	N
BM CD38⁺/T cells, %	.014	0.207	.016	Y
PB TIM-3⁺/T cells, %	.017	0.033	.687	N
PB CD3⁺/CD45⁺ lymphocytes, %	.017	0.129	.271	N
PB PD-1⁺TIM-3⁺/CD8⁺ T cells, %	.018	0.129	.116	N
PB CD38⁺ Tregs, %	.019	0.004	.964	N
BM CD38⁺/CD8⁺ T cells, %	.020	0.276	.001	Y
PB CD45⁺CD3⁺CD8⁺, ×10⁶/L	.024	–0.135	.243	N
PB Tregs/CD4⁺ T cells, %	.029	0.164	.046	Y
BM PD-1⁺TIM-3⁺/CD4⁺ T cells, %	.029	0.149	.084	N
PB PD-1⁺/T cells, %	.032	0.016	.842	N
PB PD-1⁺TIM-3⁺/CD4⁺ T cells, %	.032	0.171	.037	Y
BM PD-1⁺TIM-3⁺/T cells, %	.033	0.135	.116	N
BM TIM-3⁺/CD8⁺ T cells, %	.041	−0.052	.547	N
BM PD-1⁺CD38⁺/CD3⁺CD8⁻CD4⁺ cells, %	.042	0.324	.001	Y
BM PD-1⁺CD38⁺/CD3⁺ cells, %	.044	0.279	.004	Y

Wilcoxon rank-sum test was used to identify differences in the specified biomarkers in responders vs nonresponders (biomarker ∼ clinical response P value). Association of each biomarker to tumor burden (biomarker ∼ BMPCs, %) was assessed using the Spearman correlation, and the correlation coefficient (R_s) and P value are reported. Biomarkers are flagged as correlated with tumor burden (Y) if Spearman P value <.05.

N, no; Y, yes.

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