Association between CH and survival outcomes in multivariable analyses
| Variables . | OS . | PFS . | NRM . | Relapse . | ||||
|---|---|---|---|---|---|---|---|---|
| Adj HR (95% CI) . | P value . | Adj HR (95% CI) . | P value . | Adj SDHR (95% CI) . | P value . | Adj SDHR (95% CI) . | P value . | |
| CH negative | Ref | Ref | Ref | Ref | ||||
| CH positive | 2.47 (1.11-5.52) | .03 | 1.98 (1.02-3.82) | .04 | 3.04 (1.18-7.80) | .02 | 0.95 (0.37-2.45) | .92 |
| Recipient age at BMT (per 10 y) | 2.95 (1.44-6.08) | .003 | 2.24 (1.20-4.18) | .01 | 1.77 (0.80-3.92) | .16 | 1.59 (0.60-4.23) | .36 |
| Donor’s age (per 10 y) | 0.99 (0.69-1.42) | .94 | 0.83 (0.60-1.16) | .29 | 1.38 (0.89-2.13) | .15 | 0.43 (0.24-0.79) | .007 |
| HCT-CI | ||||||||
| 0 | Ref | Ref | Ref | Ref | ||||
| 1-2 | 1.23 (0.55-2.75) | .62 | 1.49 (0.73-3.05) | .28 | 0.92 (0.3-2.37) | .86 | 1.88 (0.61-5.80) | .27 |
| 3+ | 1.19 (0.46-3.08) | .71 | 1.50 (0.65-3.47) | .34 | 0.76 (0.26-2.22) | .61 | 2.94 (0.94-9.20) | .06 |
| No. of prior cytotoxic therapies | ||||||||
| 0 to 2 | Ref | Ref | Ref | Ref | ||||
| 3+ | 1.39 (0.64-3.02) | .41 | 1.92 (0.97-3.79) | .06 | 0.71 (0.25-2.03) | .53 | 4.53 (1.75-11.70) | .002 |
| Variables . | OS . | PFS . | NRM . | Relapse . | ||||
|---|---|---|---|---|---|---|---|---|
| Adj HR (95% CI) . | P value . | Adj HR (95% CI) . | P value . | Adj SDHR (95% CI) . | P value . | Adj SDHR (95% CI) . | P value . | |
| CH negative | Ref | Ref | Ref | Ref | ||||
| CH positive | 2.47 (1.11-5.52) | .03 | 1.98 (1.02-3.82) | .04 | 3.04 (1.18-7.80) | .02 | 0.95 (0.37-2.45) | .92 |
| Recipient age at BMT (per 10 y) | 2.95 (1.44-6.08) | .003 | 2.24 (1.20-4.18) | .01 | 1.77 (0.80-3.92) | .16 | 1.59 (0.60-4.23) | .36 |
| Donor’s age (per 10 y) | 0.99 (0.69-1.42) | .94 | 0.83 (0.60-1.16) | .29 | 1.38 (0.89-2.13) | .15 | 0.43 (0.24-0.79) | .007 |
| HCT-CI | ||||||||
| 0 | Ref | Ref | Ref | Ref | ||||
| 1-2 | 1.23 (0.55-2.75) | .62 | 1.49 (0.73-3.05) | .28 | 0.92 (0.3-2.37) | .86 | 1.88 (0.61-5.80) | .27 |
| 3+ | 1.19 (0.46-3.08) | .71 | 1.50 (0.65-3.47) | .34 | 0.76 (0.26-2.22) | .61 | 2.94 (0.94-9.20) | .06 |
| No. of prior cytotoxic therapies | ||||||||
| 0 to 2 | Ref | Ref | Ref | Ref | ||||
| 3+ | 1.39 (0.64-3.02) | .41 | 1.92 (0.97-3.79) | .06 | 0.71 (0.25-2.03) | .53 | 4.53 (1.75-11.70) | .002 |
The analysis included patient age, donor age, number of lines of cytotoxic chemotherapy, and HCT-CI score.
Adj, adjustment with patient age, donor age, HCT-CI, and lines of cytotoxic chemotherapy; NOM, number of mutations; Ref, reference.