The number of cases used for single nucleotide variant and insertions and deletions (mutations) analyses is 432, based on references Karolová et al³⁵; Yi et al³²; Nadeu et al⁵; Pararjalingam et al³⁶; Jeong et al³⁷; Jain et al³³; Agarwal et al³⁸; Yang et al³⁹; Wu et al⁴⁰; Zhang et al⁴¹; Khodadoust et al.⁴² The number of cases used for CNA is 202, based on references Yi et al³² and Nadeu et al.⁵ The number of cases used for frequencies among cMCL and nnMCL subtypes is 59 and 20, respectively, based on Nadeu et al⁵ after eliminating 3 posttreatment samples. Fisher exact test was used to compare the genomic alterations within MCL subgroups. Mutations in genes of late replicating regions⁴³ and IGH, IGK, and IGK loci have been excluded.

Del, deletion; NA, not analyzed; TLR, toll like receptor.

P value ≤ .05 was considered significant.

TERT alterations refer to promoter mutations, structural variants detected by WGS or FISH, and gains or amplifications reported in Nadeu et al.⁵