Results of baseline GAs in older adults under consideration for CAR-T
| . | All patients (N = 61) . | GA-MDC recommendation . | P value . | Receipt of CAR-T therapy . | P value . | ||
|---|---|---|---|---|---|---|---|
| Proceed (n = 48) . | Defer/Decline (n = 13) . | Recipients (n = 53) . | Nonrecipients (n = 8) . | ||||
| BMI, n (%), kg/m2 | |||||||
| 18.5-29.99 | 50 (82.0) | 40 (83.3) | 10 (76.9) | .69 | 44 (83.0) | 6 (75.0) | .63 |
| ≥30 | 11 (18.0) | 8 (16.7) | 3 (23.1) | 9 (17.0) | 2 (25.0) | ||
| Percent weight loss, n (%) | |||||||
| >5% | 27 (44.3) | 20 (41.7) | 7 (53.9) | .62 | 22 (41.5) | 5 (62.5) | .70 |
| 1%-5% | 4 (276.6) | 3 (6.2) | 1 (7.7) | 4 (7.6) | 0 (0) | ||
| No weight loss | 30 (49.2) | 25 (52.1) | 5 (38.4) | 27 (50.9) | 3 (37.5) | ||
| Albumin, n (%) | |||||||
| <3.5 | 9 (14.8) | 5 (10.4) | 4 (30.8) | .09 | 6 (11.3) | 3 (37.5) | .09 |
| ≥3.5 | 52 (85.2) | 43 (89.6) | 9 (69.2) | 47 (88.7) | 5 (62.5) | ||
| Timed up and go, n (%) | |||||||
| <13.5 seconds | 42 (84.0) | 36 (92.3) | 6 (54.6) | .01 | 38 (88.4) | 4 (57.1) | .07 |
| ≥13.5 seconds | 8 (16.0) | 3 (7.7) | 5 (45.4) | 5 (11.6) | 3 (42.9) | ||
| 6-min walk, n (%) | |||||||
| <400 m | 35 (60.3) | 23 (51.1) | 12 (92.3) | .01 | 29 (56.9) | 6 (85.7) | .23 |
| ≥400 m | 23 (39.7) | 22 (48.9) | 1 (7.7) | 22 (43.1) | 1 (14.3) | ||
| 4-meter walk, n (%) | |||||||
| Frail | 14 (24.1) | 7 (15.6) | 7 (53.9) | .01 | 10 (20.0) | 4 (50.0) | .09 |
| Not frail | 44 (75.9) | 38 (84.4) | 6 (46.1) | 40 (80.0) | 4 (50.0) | ||
| Grip strength, n (%) | |||||||
| Frail | 33 (58.9) | 22 (51.2) | 11 (84.6) | .03 | 27 (56.3) | 6 (75.0) | .45 |
| Not frail | 23 (41.1) | 21 (48.8) | 2 (15.4) | 21 (43.7) | 2 (25.0) | ||
| OARS IADL, n (%) | |||||||
| <14 | 12 (34.3) | 7 (26.9) | 5 (55.6) | .22 | 9 (31.0) | 3 (50.0) | .39 |
| ≥14 | 23 (65.7) | 19 (73.1) | 4 (44.4) | 20 (69.0) | 3 (50.0) | ||
| MOS Physical Health, n (%) | |||||||
| <90 | 24 (72.7) | 17 (68.0) | 7 (87.5) | .39 | 18 (66.7) | 6 (100.0) | .16 |
| ≥90 | 9 (27.3) | 8 (32.0) | 1 (12.5) | 9 (33.3) | 0 (0) | ||
| MHI-17, median (range) | 83.5 (67.1) | 87.1 67.1) | 79.4 (38.8) | .13 | 87.1 (67.1) | 81.2 (30.6) | .42 |
| KPS (MD-report), n (%) | |||||||
| <80 | 17 (28.3) | 8 (17.0) | 9 (69.2) | .01 | 13 (25.0) | 4 (50.0) | .21 |
| ≥80 | 43 (71.7) | 39 (83.0) | 4 (30.8) | 39 (75.0) | 4 (50.0) | ||
| KPS (Self-report), n (%) | |||||||
| <80 | 17 (28.3) | 8 (17.0) | 9 (69.2) | .01 | 13 (25.0) | 4 (50.0) | .21 |
| ≥80 | 43 (71.7) | 39 (83.0) | 4 (30.8) | 39 (75.0) | 4 (50.0) | ||
| BOMC, n (%) | |||||||
| <7 | 40 (87.0) | 30 (90.9) | 10 (76.9) | .33 | 34 (87.2) | 6 (85.7) | 1.00 |
| ≥7 | 6 (13.0) | 3 (9.1) | 3 (23.1) | 5 (12.8) | 1 (14.3) | ||
| MOCA, n (%) | |||||||
| 26-30 | 27 (57.4) | 25 (64.1) | 2 (25.0) | .08 | 25 (59.5) | 2 (40.0) | .67 |
| 19-25 | 19 (40.4) | 13 (33.3) | 6 (75.0) | 16 (38.1) | 3 (60.0) | ||
| ≤18 | 1 (2.2) | 1 (3.4) | 0 (0.0) | 1 (2.4) | 0 (0.0) | ||
| . | All patients (N = 61) . | GA-MDC recommendation . | P value . | Receipt of CAR-T therapy . | P value . | ||
|---|---|---|---|---|---|---|---|
| Proceed (n = 48) . | Defer/Decline (n = 13) . | Recipients (n = 53) . | Nonrecipients (n = 8) . | ||||
| BMI, n (%), kg/m2 | |||||||
| 18.5-29.99 | 50 (82.0) | 40 (83.3) | 10 (76.9) | .69 | 44 (83.0) | 6 (75.0) | .63 |
| ≥30 | 11 (18.0) | 8 (16.7) | 3 (23.1) | 9 (17.0) | 2 (25.0) | ||
| Percent weight loss, n (%) | |||||||
| >5% | 27 (44.3) | 20 (41.7) | 7 (53.9) | .62 | 22 (41.5) | 5 (62.5) | .70 |
| 1%-5% | 4 (276.6) | 3 (6.2) | 1 (7.7) | 4 (7.6) | 0 (0) | ||
| No weight loss | 30 (49.2) | 25 (52.1) | 5 (38.4) | 27 (50.9) | 3 (37.5) | ||
| Albumin, n (%) | |||||||
| <3.5 | 9 (14.8) | 5 (10.4) | 4 (30.8) | .09 | 6 (11.3) | 3 (37.5) | .09 |
| ≥3.5 | 52 (85.2) | 43 (89.6) | 9 (69.2) | 47 (88.7) | 5 (62.5) | ||
| Timed up and go, n (%) | |||||||
| <13.5 seconds | 42 (84.0) | 36 (92.3) | 6 (54.6) | .01 | 38 (88.4) | 4 (57.1) | .07 |
| ≥13.5 seconds | 8 (16.0) | 3 (7.7) | 5 (45.4) | 5 (11.6) | 3 (42.9) | ||
| 6-min walk, n (%) | |||||||
| <400 m | 35 (60.3) | 23 (51.1) | 12 (92.3) | .01 | 29 (56.9) | 6 (85.7) | .23 |
| ≥400 m | 23 (39.7) | 22 (48.9) | 1 (7.7) | 22 (43.1) | 1 (14.3) | ||
| 4-meter walk, n (%) | |||||||
| Frail | 14 (24.1) | 7 (15.6) | 7 (53.9) | .01 | 10 (20.0) | 4 (50.0) | .09 |
| Not frail | 44 (75.9) | 38 (84.4) | 6 (46.1) | 40 (80.0) | 4 (50.0) | ||
| Grip strength, n (%) | |||||||
| Frail | 33 (58.9) | 22 (51.2) | 11 (84.6) | .03 | 27 (56.3) | 6 (75.0) | .45 |
| Not frail | 23 (41.1) | 21 (48.8) | 2 (15.4) | 21 (43.7) | 2 (25.0) | ||
| OARS IADL, n (%) | |||||||
| <14 | 12 (34.3) | 7 (26.9) | 5 (55.6) | .22 | 9 (31.0) | 3 (50.0) | .39 |
| ≥14 | 23 (65.7) | 19 (73.1) | 4 (44.4) | 20 (69.0) | 3 (50.0) | ||
| MOS Physical Health, n (%) | |||||||
| <90 | 24 (72.7) | 17 (68.0) | 7 (87.5) | .39 | 18 (66.7) | 6 (100.0) | .16 |
| ≥90 | 9 (27.3) | 8 (32.0) | 1 (12.5) | 9 (33.3) | 0 (0) | ||
| MHI-17, median (range) | 83.5 (67.1) | 87.1 67.1) | 79.4 (38.8) | .13 | 87.1 (67.1) | 81.2 (30.6) | .42 |
| KPS (MD-report), n (%) | |||||||
| <80 | 17 (28.3) | 8 (17.0) | 9 (69.2) | .01 | 13 (25.0) | 4 (50.0) | .21 |
| ≥80 | 43 (71.7) | 39 (83.0) | 4 (30.8) | 39 (75.0) | 4 (50.0) | ||
| KPS (Self-report), n (%) | |||||||
| <80 | 17 (28.3) | 8 (17.0) | 9 (69.2) | .01 | 13 (25.0) | 4 (50.0) | .21 |
| ≥80 | 43 (71.7) | 39 (83.0) | 4 (30.8) | 39 (75.0) | 4 (50.0) | ||
| BOMC, n (%) | |||||||
| <7 | 40 (87.0) | 30 (90.9) | 10 (76.9) | .33 | 34 (87.2) | 6 (85.7) | 1.00 |
| ≥7 | 6 (13.0) | 3 (9.1) | 3 (23.1) | 5 (12.8) | 1 (14.3) | ||
| MOCA, n (%) | |||||||
| 26-30 | 27 (57.4) | 25 (64.1) | 2 (25.0) | .08 | 25 (59.5) | 2 (40.0) | .67 |
| 19-25 | 19 (40.4) | 13 (33.3) | 6 (75.0) | 16 (38.1) | 3 (60.0) | ||
| ≤18 | 1 (2.2) | 1 (3.4) | 0 (0.0) | 1 (2.4) | 0 (0.0) | ||
KPS, Karnofsky performance status; MHI-17, Mental Health Index-17.