Univariate and multivariate analysis: effects of each values on OS/PFS
| . | Univariate analysis . | Multivariate analysis . | ||
|---|---|---|---|---|
| Hazard ratio (95% CI) . | P value . | Hazard ratio (95% CI) . | P value . | |
| Effects of pretreatment values on OS | ||||
| Age (≥65 vs <65), y | 0.93 (0.39-2.26) | .881 | ||
| Sex (male vs female) | 3.09 (1.26-7.58) | .014 | 3.47 (1.26-9.57) | .016 |
| sIL-2R (≥10 000 vs <10 000) | 1.61 (0.63-4.03) | .313 | ||
| LDH (≥1.5 times UNL vs <1.5 times UNL) | 1.81 (0.60-5.42) | .293 | ||
| N/P (≥12.5 vs <12.5) | 3.75 (1.43-9.87) | .007 | 4.35 (1.23-15.44) | .023 |
| Effects of values after 1 course treatment on OS | ||||
| Age (≥65 vs <65) | 0.90 (0.37-2.17) | .814 | ||
| Sex (male vs female) | 3.15 (1.29-7.73) | .012 | 4.12 (1.63-10.42) | .003 |
| sIL-2R (≥5 000 vs <5 000) | 2.64 (1.09-6.42) | .032 | ||
| LDH (≥UNL vs <UNL) | 1.70 (0.57-5.08) | .345 | ||
| N fraction (≥85 vs <85), % | 4.74 (1.86-12.11) | .001 | 5.37 (1.71-16.86) | .004 |
| Effects of values after 1 course treatment on PFS | ||||
| Age (≥65 vs <65) | 0.61 (0.28-1.33) | .217 | ||
| Sex (male vs female) | 2.22 (1.00-4.93) | .049 | 3.29 (1.33-8.11) | .01 |
| sIL-2R (≥5000 vs <5000) | 1.33 (0.61-2.91) | .472 | ||
| LDH (≥UNL vs <UNL) | 1.06 (0.44-2.54) | .895 | ||
| N fraction (≥85 vs <85), % | 3.97 (1.64-9.65) | .002 | 5.90 (1.92-18.10) | .002 |
| Effects of pretransplant values on OS | ||||
| Age (≥65 vs <65) | 1.00 (0.39-2.60) | .999 | ||
| Sex (male vs female) | 3.81 (1.24-11.70) | .02 | 5.54 (1.58-19.43) | .007 |
| sIL-2R (≥2000 vs <2000) | 0.79 (0.28-2.24) | .655 | ||
| LDH (≥UNL vs <UNL) | 1.20 (0.46-3.12) | .706 | ||
| N fraction (%) (≥40 vs <40) | 2.65 (0.99-7.10) | .053 | 3.36 (1.10-10.26) | .033 |
| Effects of pretransplant values on PFS | ||||
| Age (≥65 vs <65) | 0.87 (0.35-2.12) | .75 | ||
| Sex (male vs female) | 2.58 (1.02-6.53) | .045 | 6.41 (1.99-20.70) | .002 |
| sIL-2R (≥2000 vs <2000) | 1.25 (0.50-3.13) | .637 | ||
| LDH (≥UNL vs <UNL) | 1.26 (0.52-3.04) | .602 | ||
| N fraction (≥40 vs <40), % | 3.64 (1.40-9.44) | .008 | 5.03 (1.82-13.91) | .002 |
| . | Univariate analysis . | Multivariate analysis . | ||
|---|---|---|---|---|
| Hazard ratio (95% CI) . | P value . | Hazard ratio (95% CI) . | P value . | |
| Effects of pretreatment values on OS | ||||
| Age (≥65 vs <65), y | 0.93 (0.39-2.26) | .881 | ||
| Sex (male vs female) | 3.09 (1.26-7.58) | .014 | 3.47 (1.26-9.57) | .016 |
| sIL-2R (≥10 000 vs <10 000) | 1.61 (0.63-4.03) | .313 | ||
| LDH (≥1.5 times UNL vs <1.5 times UNL) | 1.81 (0.60-5.42) | .293 | ||
| N/P (≥12.5 vs <12.5) | 3.75 (1.43-9.87) | .007 | 4.35 (1.23-15.44) | .023 |
| Effects of values after 1 course treatment on OS | ||||
| Age (≥65 vs <65) | 0.90 (0.37-2.17) | .814 | ||
| Sex (male vs female) | 3.15 (1.29-7.73) | .012 | 4.12 (1.63-10.42) | .003 |
| sIL-2R (≥5 000 vs <5 000) | 2.64 (1.09-6.42) | .032 | ||
| LDH (≥UNL vs <UNL) | 1.70 (0.57-5.08) | .345 | ||
| N fraction (≥85 vs <85), % | 4.74 (1.86-12.11) | .001 | 5.37 (1.71-16.86) | .004 |
| Effects of values after 1 course treatment on PFS | ||||
| Age (≥65 vs <65) | 0.61 (0.28-1.33) | .217 | ||
| Sex (male vs female) | 2.22 (1.00-4.93) | .049 | 3.29 (1.33-8.11) | .01 |
| sIL-2R (≥5000 vs <5000) | 1.33 (0.61-2.91) | .472 | ||
| LDH (≥UNL vs <UNL) | 1.06 (0.44-2.54) | .895 | ||
| N fraction (≥85 vs <85), % | 3.97 (1.64-9.65) | .002 | 5.90 (1.92-18.10) | .002 |
| Effects of pretransplant values on OS | ||||
| Age (≥65 vs <65) | 1.00 (0.39-2.60) | .999 | ||
| Sex (male vs female) | 3.81 (1.24-11.70) | .02 | 5.54 (1.58-19.43) | .007 |
| sIL-2R (≥2000 vs <2000) | 0.79 (0.28-2.24) | .655 | ||
| LDH (≥UNL vs <UNL) | 1.20 (0.46-3.12) | .706 | ||
| N fraction (%) (≥40 vs <40) | 2.65 (0.99-7.10) | .053 | 3.36 (1.10-10.26) | .033 |
| Effects of pretransplant values on PFS | ||||
| Age (≥65 vs <65) | 0.87 (0.35-2.12) | .75 | ||
| Sex (male vs female) | 2.58 (1.02-6.53) | .045 | 6.41 (1.99-20.70) | .002 |
| sIL-2R (≥2000 vs <2000) | 1.25 (0.50-3.13) | .637 | ||
| LDH (≥UNL vs <UNL) | 1.26 (0.52-3.04) | .602 | ||
| N fraction (≥40 vs <40), % | 3.64 (1.40-9.44) | .008 | 5.03 (1.82-13.91) | .002 |
UNL, upper normal limit.