Table 3.

Comparing 5 different methods to define vitamin D exposure, each was analyzed separately within a multivariate Cox model for TTFT and TFS presented inTable 2 

Vitamin D or analog representationTTFTTFS
Hazard ratioP valueHazard ratioP value
Current vitamin D use (binary) 0.992 (0.61-1.615) .975 0.961 (0.855-1.065) .066 
Cumulative vitamin D use 0.954 (0.861-1.047) .651 0.922 (0.972-1.013) .223 
Current vitamin D dose 1 (0.999-1) .264 0.933 (0.882-1.012) .179 
Log (current vitamin D dose) 0.879 (0.762-1.014) .077 0.912 (0.856-0.971) .004 
Cumulative vitamin D dose 1 (1-1) .659 0.984 (0.982-1.02) .421 
Current analog use 0.965 (0.937-0.993) .266 0.71 (0.461-1.122) .091 
Cumulative analog use 0.976 (0.965-0.988) .767 0.927 (0.923-1.042) .182 
Current analog dose 0.968 (0.899-1.036) .092 0.936 (0.995-1.001) .056 
Log (analog dose) 0.97 (0.913-1.027) .181 0.951 (0.882-1.015) .082 
Cumulative analog dose 1 (1-1) .372 1 (1-1) .418 
Vitamin D or analog representationTTFTTFS
Hazard ratioP valueHazard ratioP value
Current vitamin D use (binary) 0.992 (0.61-1.615) .975 0.961 (0.855-1.065) .066 
Cumulative vitamin D use 0.954 (0.861-1.047) .651 0.922 (0.972-1.013) .223 
Current vitamin D dose 1 (0.999-1) .264 0.933 (0.882-1.012) .179 
Log (current vitamin D dose) 0.879 (0.762-1.014) .077 0.912 (0.856-0.971) .004 
Cumulative vitamin D dose 1 (1-1) .659 0.984 (0.982-1.02) .421 
Current analog use 0.965 (0.937-0.993) .266 0.71 (0.461-1.122) .091 
Cumulative analog use 0.976 (0.965-0.988) .767 0.927 (0.923-1.042) .182 
Current analog dose 0.968 (0.899-1.036) .092 0.936 (0.995-1.001) .056 
Log (analog dose) 0.97 (0.913-1.027) .181 0.951 (0.882-1.015) .082 
Cumulative analog dose 1 (1-1) .372 1 (1-1) .418 
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