Comparing 5 different methods to define vitamin D exposure, each was analyzed separately within a multivariate Cox model for TTFT and TFS presented inTable 2
Vitamin D or analog representation . | TTFT . | TFS . | ||
---|---|---|---|---|
Hazard ratio . | P value . | Hazard ratio . | P value . | |
Current vitamin D use (binary) | 0.992 (0.61-1.615) | .975 | 0.961 (0.855-1.065) | .066 |
Cumulative vitamin D use | 0.954 (0.861-1.047) | .651 | 0.922 (0.972-1.013) | .223 |
Current vitamin D dose | 1 (0.999-1) | .264 | 0.933 (0.882-1.012) | .179 |
Log (current vitamin D dose) | 0.879 (0.762-1.014) | .077 | 0.912 (0.856-0.971) | .004 |
Cumulative vitamin D dose | 1 (1-1) | .659 | 0.984 (0.982-1.02) | .421 |
Current analog use | 0.965 (0.937-0.993) | .266 | 0.71 (0.461-1.122) | .091 |
Cumulative analog use | 0.976 (0.965-0.988) | .767 | 0.927 (0.923-1.042) | .182 |
Current analog dose | 0.968 (0.899-1.036) | .092 | 0.936 (0.995-1.001) | .056 |
Log (analog dose) | 0.97 (0.913-1.027) | .181 | 0.951 (0.882-1.015) | .082 |
Cumulative analog dose | 1 (1-1) | .372 | 1 (1-1) | .418 |
Vitamin D or analog representation . | TTFT . | TFS . | ||
---|---|---|---|---|
Hazard ratio . | P value . | Hazard ratio . | P value . | |
Current vitamin D use (binary) | 0.992 (0.61-1.615) | .975 | 0.961 (0.855-1.065) | .066 |
Cumulative vitamin D use | 0.954 (0.861-1.047) | .651 | 0.922 (0.972-1.013) | .223 |
Current vitamin D dose | 1 (0.999-1) | .264 | 0.933 (0.882-1.012) | .179 |
Log (current vitamin D dose) | 0.879 (0.762-1.014) | .077 | 0.912 (0.856-0.971) | .004 |
Cumulative vitamin D dose | 1 (1-1) | .659 | 0.984 (0.982-1.02) | .421 |
Current analog use | 0.965 (0.937-0.993) | .266 | 0.71 (0.461-1.122) | .091 |
Cumulative analog use | 0.976 (0.965-0.988) | .767 | 0.927 (0.923-1.042) | .182 |
Current analog dose | 0.968 (0.899-1.036) | .092 | 0.936 (0.995-1.001) | .056 |
Log (analog dose) | 0.97 (0.913-1.027) | .181 | 0.951 (0.882-1.015) | .082 |
Cumulative analog dose | 1 (1-1) | .372 | 1 (1-1) | .418 |