Multivariable negative binomial models for visits per year using 3 ordinal transfer gap categories
| Encounter type and transfer gap in months . | Full study sample (N = 183), rate ratios (95% CI) . | Sensitivity analysis Sample excludes those with potential missing adult encounters (n = 169), rate ratios (95% CI) . | ||
|---|---|---|---|---|
| 2012-2020 . | First 2 y in adult care . | 2012-2020 . | First 2 y in adult care . | |
| All acute visits∗ | ||||
| <2 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| ≥2 to <6 | 1.27 (0.81-2.00) | 1.31 (0.88-1.95) | 1.06 (0.65-1.72) | 1.04 (0.69-1.58) |
| ≥6 | 1.58 (1.01-2.48) | 1.82 (1.22-2.71) | 1.69 (1.05-2.72) | 1.86 (1.25-2.79) |
| Inpatient visits | ||||
| <2 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| ≥2 to <6 | 1.01 (0.63-1.61) | 1.10 (0.65-1.82) | 0.81 (0.50-1.31) | 0.81 (0.47-1.41) |
| ≥6 | 2.01 (1.31-3.11) | 1.89 (1.17-3.04) | 2.24 (1.44-3.47) | 1.96 (1.22-3.17) |
| ED visits | ||||
| <2 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| ≥2 to <6 | 1.33 (0.78-2.28) | 1.39 (0.87-2.22) | 1.13 (0.63-2.02) | 1.15 (0.70-1.88) |
| ≥6 | 1.37 (0.80-2.33) | 1.75 (1.10-2.80) | 1.41 (0.80-2.51) | 1.80 (1.11-2.92) |
| Outpatient visits | ||||
| <2 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| ≥2 to <6 | 0.71 (0.53-0.96) | 0.71 (0.53-0.95) | 0.69 (0.51-0.93) | 0.67 (0.49-0.91) |
| ≥6 | 0.84 (0.62-1.15) | 0.78 (0.57-1.07) | 0.90 (0.66-1.23) | 0.80 (0.58-1.11) |
| Encounter type and transfer gap in months . | Full study sample (N = 183), rate ratios (95% CI) . | Sensitivity analysis Sample excludes those with potential missing adult encounters (n = 169), rate ratios (95% CI) . | ||
|---|---|---|---|---|
| 2012-2020 . | First 2 y in adult care . | 2012-2020 . | First 2 y in adult care . | |
| All acute visits∗ | ||||
| <2 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| ≥2 to <6 | 1.27 (0.81-2.00) | 1.31 (0.88-1.95) | 1.06 (0.65-1.72) | 1.04 (0.69-1.58) |
| ≥6 | 1.58 (1.01-2.48) | 1.82 (1.22-2.71) | 1.69 (1.05-2.72) | 1.86 (1.25-2.79) |
| Inpatient visits | ||||
| <2 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| ≥2 to <6 | 1.01 (0.63-1.61) | 1.10 (0.65-1.82) | 0.81 (0.50-1.31) | 0.81 (0.47-1.41) |
| ≥6 | 2.01 (1.31-3.11) | 1.89 (1.17-3.04) | 2.24 (1.44-3.47) | 1.96 (1.22-3.17) |
| ED visits | ||||
| <2 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| ≥2 to <6 | 1.33 (0.78-2.28) | 1.39 (0.87-2.22) | 1.13 (0.63-2.02) | 1.15 (0.70-1.88) |
| ≥6 | 1.37 (0.80-2.33) | 1.75 (1.10-2.80) | 1.41 (0.80-2.51) | 1.80 (1.11-2.92) |
| Outpatient visits | ||||
| <2 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| ≥2 to <6 | 0.71 (0.53-0.96) | 0.71 (0.53-0.95) | 0.69 (0.51-0.93) | 0.67 (0.49-0.91) |
| ≥6 | 0.84 (0.62-1.15) | 0.78 (0.57-1.07) | 0.90 (0.66-1.23) | 0.80 (0.58-1.11) |
The models are adjusted for genotype severity, pediatric inpatient visit count, pediatric ED visit count, pediatric outpatient visit count, insurance, hydroxyurea utilization, and chronic transfusion therapy.
Ref, reference.
Bolded values indicate a significant association with a type I error rate at 0.05.
Acute care visits include both inpatient and ED visits.