Table 1.

CRS-RS and CRS-RS.5p model parameters

Parameter and cut-offCRS-RS CRS-RS.5p, Weight
Age > 64 y X  
LDH,§ > 280 U/L  X  X  0.5 
WBC§, > 4.5 × 109 cells/L X  X  0.5 
Ann Arbor stage III/IV  X  X  
SPD ≥ 3000 mm3 X  X  
Cardiac comorbidity#,∗∗  X  – 0.5 
Bone marrow infiltration∗∗  X  – 
Atypical cells in peripheral blood∗∗  X  – 
Parameter and cut-offCRS-RS CRS-RS.5p, Weight
Age > 64 y X  
LDH,§ > 280 U/L  X  X  0.5 
WBC§, > 4.5 × 109 cells/L X  X  0.5 
Ann Arbor stage III/IV  X  X  
SPD ≥ 3000 mm3 X  X  
Cardiac comorbidity#,∗∗  X  – 0.5 
Bone marrow infiltration∗∗  X  – 
Atypical cells in peripheral blood∗∗  X  – 

LDH, lactate dehydrogenase; SPD, the sum of the product of the perpendicular diameters; WBC, white blood cell; y, years.

The original CRS-RS model used 8 baseline factors and the streamlined CRS-RS.5p model used 5 baseline factors.

Cut-off values for low-risk and high-risk were <4 and ≥4, respectively.

Age, Ann Arbor stage, and LDH levels reflect the aggressiveness of lymphomas and are included in International Prognostic Index scores.11 

§

Pre–anti-CD20 treatment.

Commonly considered as the upper limit of normal.

WBC and SPD have been selected to reflect target-effector cell interaction.

#

Cardiac comorbidities reflect the baseline state of cardiovascular compartments relevant to T-cell activation.

∗∗

Presence of cardiac comorbidity, bone marrow infiltration, and atypical cells in peripheral blood have been excluded as parameters in the streamlined model to facilitate clinical application of the risk score without adversely impacting its performance.

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