Clinical and genetic characteristics of participants
| Characteristic . | Control (n = 13) . | Variant (n = 11) . |
|---|---|---|
| Variant | — | rs74355478 |
| Genotype | Wild type (G/G) | Homozygous (−/−) |
| LGR6 genomic change (GRCh37) | — | g.202183358del |
| LGR6 cDNA (GRCh37) | — | c.1:202183357-TG-T |
| LGR6 protein change (NP_001017404.1) | — | p.Ala26ArgfsTer7 |
| Sex (n) | Males (5); females (8) | Males (4); females (7) |
| Age (range), y | 56 (40-67) | 53 (38-73) |
| Comorbidities (n) | Diabetes (3), heart disease (4), high blood pressure (3), high cholesterol (6), back pain (2), arthritis (2), asthma (2), allergies (2), bowel cancer (remission; 1), depression (1), constipation (1), fatigue (1), joint pain (1), low blood pressure (1), thyroid disease (1), and reduced mobility (1) | Diabetes (5), heart disease (2), high blood pressure (3), high cholesterol (6), back pain (2), arthritis (2), asthma (2), allergies (4), bowel cancer (remission; 1), angina (2), depression (3), reduced mobility (1), regular infections (1), memory loss (1), polycystic ovary syndrome (1), and irritable bowel syndrome (2) |
| Supplements intake | Multivitamins (3), iron supplement (3), calcium tablets (1), fish oil tablets (1), vitamin D (7), folic acid (2), and vitamin B (1) | Multivitamins (2), iron supplement (1), folic acid (1), calcium tablets (2), fish oil tablets (1), vitamin D (4), and vitamin B (1) |
| Characteristic . | Control (n = 13) . | Variant (n = 11) . |
|---|---|---|
| Variant | — | rs74355478 |
| Genotype | Wild type (G/G) | Homozygous (−/−) |
| LGR6 genomic change (GRCh37) | — | g.202183358del |
| LGR6 cDNA (GRCh37) | — | c.1:202183357-TG-T |
| LGR6 protein change (NP_001017404.1) | — | p.Ala26ArgfsTer7 |
| Sex (n) | Males (5); females (8) | Males (4); females (7) |
| Age (range), y | 56 (40-67) | 53 (38-73) |
| Comorbidities (n) | Diabetes (3), heart disease (4), high blood pressure (3), high cholesterol (6), back pain (2), arthritis (2), asthma (2), allergies (2), bowel cancer (remission; 1), depression (1), constipation (1), fatigue (1), joint pain (1), low blood pressure (1), thyroid disease (1), and reduced mobility (1) | Diabetes (5), heart disease (2), high blood pressure (3), high cholesterol (6), back pain (2), arthritis (2), asthma (2), allergies (4), bowel cancer (remission; 1), angina (2), depression (3), reduced mobility (1), regular infections (1), memory loss (1), polycystic ovary syndrome (1), and irritable bowel syndrome (2) |
| Supplements intake | Multivitamins (3), iron supplement (3), calcium tablets (1), fish oil tablets (1), vitamin D (7), folic acid (2), and vitamin B (1) | Multivitamins (2), iron supplement (1), folic acid (1), calcium tablets (2), fish oil tablets (1), vitamin D (4), and vitamin B (1) |
cDNA, complementary DNA.