Comparison of sensitivities, specificities, Youden’s indices, and likelihood ratios among SM screening tests
| . | Sensitivity % . | Specificity % . | Youden’s index . | LR+ . | LR– . |
|---|---|---|---|---|---|
| BST ≥11.5 ng/mL (n = 136) | 88.3 | 23.8 | 0.12 | 1.16 (0.96-1.39) | 0.49 (0.23-1.07) |
| BST ≥20.0 ng/mL (n = 136) | 59.6 | 71.4 | 0.31 | 2.09 (1.26-3.46) | 0.57 (0.41-0.77) |
| BST elevated based upon genotype (n = 117) | 84.2 | 90.2 | 0.74 | 8.63 (3.39-22.00) | 0.17 (0.10-0.30) |
| REMA ≥2 (n = 136) | 34.0 | 73.8 | 0.08 | 1.30 (0.73-2.32) | 0.89 (0.71-1.13) |
| REMA ≥2 and BST elevated based upon genotype (n = 117) | 30.3 | 97.6 | 0.28 | 12.00 (1.74-89.00) | 0.71 (0.61-0.84) |
| Monomorphic MPCM (n = 136) | 63.8 | 97.6 | 0.61 | 27.00 (3.84-187.00) | 0.37 (0.28-0.49) |
| . | Sensitivity % . | Specificity % . | Youden’s index . | LR+ . | LR– . |
|---|---|---|---|---|---|
| BST ≥11.5 ng/mL (n = 136) | 88.3 | 23.8 | 0.12 | 1.16 (0.96-1.39) | 0.49 (0.23-1.07) |
| BST ≥20.0 ng/mL (n = 136) | 59.6 | 71.4 | 0.31 | 2.09 (1.26-3.46) | 0.57 (0.41-0.77) |
| BST elevated based upon genotype (n = 117) | 84.2 | 90.2 | 0.74 | 8.63 (3.39-22.00) | 0.17 (0.10-0.30) |
| REMA ≥2 (n = 136) | 34.0 | 73.8 | 0.08 | 1.30 (0.73-2.32) | 0.89 (0.71-1.13) |
| REMA ≥2 and BST elevated based upon genotype (n = 117) | 30.3 | 97.6 | 0.28 | 12.00 (1.74-89.00) | 0.71 (0.61-0.84) |
| Monomorphic MPCM (n = 136) | 63.8 | 97.6 | 0.61 | 27.00 (3.84-187.00) | 0.37 (0.28-0.49) |
Patients were included in this analysis only if they had either (1) a BMB or (2) detectable KIT p.D816V in PB. For the LR+ and LR–, the numbers in brackets represent the 95% confidence intervals. Youden’s index = (sensitivity + specificity) – 1.