Five-year estimates for OS for patients with greater than 5% blasts at diagnosis
| Pretreatment . | Blast change . | IPSS-R score at diagnosis . | |||
|---|---|---|---|---|---|
| Low . | Intermediate . | High . | Very high . | ||
| Untreated | Same | 67 (55-82) | 56 (46-68) | 46 (36-60) | 31 (20-47) |
| Lower at HCT | 46 (28-76) | 33 (18-59) | 23 (10-51) | 10 (3-37) | |
| Chemotherapy | Same | 56 (41-77) | 44 (32-60) | 33 (22-50) | 18 (10-36) |
| Lower at HCT | 69 (58-82) | 59 (50-68) | 49 (41-60) | 34 (25-45) | |
| HMAs | Same | 58 (44-77) | 46 (35-60) | 36 (25-50) | 20 (12-35) |
| Lower at HCT | 64 (51-80) | 53 (43-65) | 43 (33-56) | 27 (18-40) | |
| Other | Same | 57 (39-81) | 44 (30-65) | 34 (20-56) | 19 (9-41) |
| Lower at HCT | 59 (45-78) | 47 (35-61) | 36 (25-52) | 21 (12-37) | |
| Pretreatment . | Blast change . | IPSS-R score at diagnosis . | |||
|---|---|---|---|---|---|
| Low . | Intermediate . | High . | Very high . | ||
| Untreated | Same | 67 (55-82) | 56 (46-68) | 46 (36-60) | 31 (20-47) |
| Lower at HCT | 46 (28-76) | 33 (18-59) | 23 (10-51) | 10 (3-37) | |
| Chemotherapy | Same | 56 (41-77) | 44 (32-60) | 33 (22-50) | 18 (10-36) |
| Lower at HCT | 69 (58-82) | 59 (50-68) | 49 (41-60) | 34 (25-45) | |
| HMAs | Same | 58 (44-77) | 46 (35-60) | 36 (25-50) | 20 (12-35) |
| Lower at HCT | 64 (51-80) | 53 (43-65) | 43 (33-56) | 27 (18-40) | |
| Other | Same | 57 (39-81) | 44 (30-65) | 34 (20-56) | 19 (9-41) |
| Lower at HCT | 59 (45-78) | 47 (35-61) | 36 (25-52) | 21 (12-37) | |
Predicted 5-year OS, expressed in percentages (with 95% CIs), based on the multivariable Cox model including the interaction between pretreatment and change in blast count.
Estimates are given for each IPSS-R category at diagnosis for reference patients with age 60 years, receiving a graft from a related donor after reduced intensity conditioning, and receiving transplantation 9 months after diagnosis.
Blast change was coded “same” when >5% at transplant, and “lower at HCT” when ≤5%.