Five-year estimates for OS for patients with less than or equal to 5% blasts at diagnosis
| Pretreatment . | Blast change . | IPSS-R score at diagnosis . | ||||
|---|---|---|---|---|---|---|
| Very low . | Low . | Intermediate . | High . | Very high . | ||
| Untreated | Same | 75 (65-86) | 70 (61-79) | 64 (54-75) | 44 (32-60) | 45 (28-73) |
| Higher at HCT | 70 (57-86) | 64 (53-78) | 57 (45-73) | 36 (23-57) | 37 (19-71) | |
| Chemotherapy | Same | 67 (55-83) | 61 (51-73) | 54 (43-67) | 32 (20-52) | 33 (17-64) |
| Higher at HCT | 50 (32-76) | 41 (27-64) | 33 (20-57) | 13 (5-38) | 14 (4-55) | |
| HMAs | Same | 58 (43-80) | 51 (37-69) | 43 (30-62) | 22 (10-45) | 23 (9-58) |
| Higher at HCT | 67 (50-89) | 60 (44-83) | 53 (36-78) | 32 (16-63) | 33 (14-78) | |
| Other | Same | 58 (43-79) | 51 (38-68) | 43 (30-62) | 21 (11-44) | 23 (9-57) |
| Higher at HCT | 66 (45-95) | 59 (38-90) | 52 (31-87) | 30 (11-81) | 31 (11-88) | |
| Pretreatment . | Blast change . | IPSS-R score at diagnosis . | ||||
|---|---|---|---|---|---|---|
| Very low . | Low . | Intermediate . | High . | Very high . | ||
| Untreated | Same | 75 (65-86) | 70 (61-79) | 64 (54-75) | 44 (32-60) | 45 (28-73) |
| Higher at HCT | 70 (57-86) | 64 (53-78) | 57 (45-73) | 36 (23-57) | 37 (19-71) | |
| Chemotherapy | Same | 67 (55-83) | 61 (51-73) | 54 (43-67) | 32 (20-52) | 33 (17-64) |
| Higher at HCT | 50 (32-76) | 41 (27-64) | 33 (20-57) | 13 (5-38) | 14 (4-55) | |
| HMAs | Same | 58 (43-80) | 51 (37-69) | 43 (30-62) | 22 (10-45) | 23 (9-58) |
| Higher at HCT | 67 (50-89) | 60 (44-83) | 53 (36-78) | 32 (16-63) | 33 (14-78) | |
| Other | Same | 58 (43-79) | 51 (38-68) | 43 (30-62) | 21 (11-44) | 23 (9-57) |
| Higher at HCT | 66 (45-95) | 59 (38-90) | 52 (31-87) | 30 (11-81) | 31 (11-88) | |
Predicted 5-year OS, expressed in percentages (with 95% CIs), based on the multivariable Cox model including the interaction between pretreatment and change in blast count.
Estimates are given for each IPSS-R category at diagnosis for reference patients with age 60 years, receiving a graft from a related donor after reduced intensity conditioning, and receiving transplantation 9 months after diagnosis.
Blast change was coded “same” when ≤5% at transplant, and “higher at HCT” when >5%.