Model-based estimates for 5-year OS for reference patients according to IPSS-R score at diagnosis, prior therapy and change in IPSS-R score
Pretreatment . | IPSS-R score change . | IPSS-R score at diagnosis . | ||||
|---|---|---|---|---|---|---|
| Very low . | Low . | Intermediate . | High . | Very high . | ||
| Untreated | Same | 74 (63-85) | 67 (59-76) | 55 (47-65) | 42 (33-54) | 28 (19-42) |
| Improving | 65 (55-78) | 54 (43-67) | 40 (29-56) | 26 (16-44) | ||
| Progressive | 75 (65-85) | 68 (60-77) | 57 (48-67) | 44 (34-56) | ||
| Chemotherapy | Same | 64 (51-80) | 55 (46-67) | 42 (32-55) | 28 (19-42) | 16 (8-29) |
| Improving | 72 (65-80) | 62 (55-69) | 50 (42-58) | 36 (28-46) | ||
| Progressive | 61 (48-78) | 52 (42-65) | 38 (28-52) | 25 (15-41) | ||
| HMAs | Same | 73 (62-86) | 66 (56-77) | 54 (44-66) | 41 (30-56) | 27 (17-43) |
| Improving | 66 (57-76) | 54 (46-64) | 41 (32-52) | 27 (19-38) | ||
| Progressive | 53 (39-74) | 44 (32-60) | 30 (19-46) | 17 (9-33) | ||
| Other | Same | 64 (50-83) | 56 (43-73) | 43 (30-60) | 29 (17-49) | 16 (8-35) |
| Improving | 64 (55-76) | 52 (42-64) | 39 (29-52) | 25 (16-39) | ||
| Progressive | 53 (38-74) | 43 (31-61) | 29 (18-48) | 17 (8-35) | ||
Pretreatment . | IPSS-R score change . | IPSS-R score at diagnosis . | ||||
|---|---|---|---|---|---|---|
| Very low . | Low . | Intermediate . | High . | Very high . | ||
| Untreated | Same | 74 (63-85) | 67 (59-76) | 55 (47-65) | 42 (33-54) | 28 (19-42) |
| Improving | 65 (55-78) | 54 (43-67) | 40 (29-56) | 26 (16-44) | ||
| Progressive | 75 (65-85) | 68 (60-77) | 57 (48-67) | 44 (34-56) | ||
| Chemotherapy | Same | 64 (51-80) | 55 (46-67) | 42 (32-55) | 28 (19-42) | 16 (8-29) |
| Improving | 72 (65-80) | 62 (55-69) | 50 (42-58) | 36 (28-46) | ||
| Progressive | 61 (48-78) | 52 (42-65) | 38 (28-52) | 25 (15-41) | ||
| HMAs | Same | 73 (62-86) | 66 (56-77) | 54 (44-66) | 41 (30-56) | 27 (17-43) |
| Improving | 66 (57-76) | 54 (46-64) | 41 (32-52) | 27 (19-38) | ||
| Progressive | 53 (39-74) | 44 (32-60) | 30 (19-46) | 17 (9-33) | ||
| Other | Same | 64 (50-83) | 56 (43-73) | 43 (30-60) | 29 (17-49) | 16 (8-35) |
| Improving | 64 (55-76) | 52 (42-64) | 39 (29-52) | 25 (16-39) | ||
| Progressive | 53 (38-74) | 43 (31-61) | 29 (18-48) | 17 (8-35) | ||
Predicted 5-year OS, expressed in percentages (with 95% CIs), based on the multivariable Cox model including the interaction between pretreatment and change in IPSS-R score.Estimates are given for each IPSS-R categories at diagnosis for reference patients with age 60 years, receiving a graft from a related donor after reduced intensity conditioning, and receiving transplantation 9 months after diagnosis. IPSS-R score change was coded as improving when IPSS-R risk was at least 1 category lower at transplant than at diagnosis, or as progressive when IPSS-R score at transplant was at least 1 category higher.