Multivariable analysis for OS
| Risk factor . | Group . | N . | D . | HR (95% CI) . | P . |
|---|---|---|---|---|---|
| Pretreatment × IPSS-R score change | |||||
| Chemotherapy | Same | 120 | 63 | ||
| Improving | 317 | 142 | 0.55 (0.41-0.76) | <.001 | |
| Progressive | 94 | 51 | 1.11 (0.76-1.61) | .6 | |
| HMAs | Same | 91 | 44 | ||
| Improving | 175 | 93 | 1.00 (0.69-1.43) | >.99 | |
| Progressive | 61 | 38 | 1.98 (1.27-3.07) | .002 | |
| Other | Same | 47 | 28 | ||
| Improving | 96 | 56 | 0.77 (0.48-1.21) | .3 | |
| Progressive | 53 | 33 | 1.45 (0.87-2.42) | .16 | |
| Untreated | Same | 170 | 70 | ||
| Improving | 67 | 35 | 1.05 (0.70-1.58) | .8 | |
| Progressive | 186 | 70 | 0.95 (0.68-1.34) | .8 | |
| Adjustment factors | |||||
| IPSS-R score at diagnosis | Very low | 81 | 27 | ||
| Low | 317 | 127 | 1.31 (0.86-2.00) | .2 | |
| Intermediate | 468 | 216 | 1.94 (1.27-2.96) | .002 | |
| High | 389 | 208 | 2.81 (1.81-4.35) | <.001 | |
| Very high | 222 | 145 | 4.12 (2.60-6.54) | <.001 | |
| Interval from diagnosis to HCT | 1477 | 723 | 1.05 (1.01-1.09) | .02 | |
| Age at HCT (dec) | 1477 | 723 | 1.12 (1.04-1.21) | .004 | |
| Conditioning | Standard | 493 | 223 | ||
| Reduced | 984 | 500 | 1.06 (0.9-1.26) | .5 | |
| Donor | Related | 533 | 245 | ||
| Unrelated | 944 | 478 | 1.19 (1.02-1.39) | .03 |
| Risk factor . | Group . | N . | D . | HR (95% CI) . | P . |
|---|---|---|---|---|---|
| Pretreatment × IPSS-R score change | |||||
| Chemotherapy | Same | 120 | 63 | ||
| Improving | 317 | 142 | 0.55 (0.41-0.76) | <.001 | |
| Progressive | 94 | 51 | 1.11 (0.76-1.61) | .6 | |
| HMAs | Same | 91 | 44 | ||
| Improving | 175 | 93 | 1.00 (0.69-1.43) | >.99 | |
| Progressive | 61 | 38 | 1.98 (1.27-3.07) | .002 | |
| Other | Same | 47 | 28 | ||
| Improving | 96 | 56 | 0.77 (0.48-1.21) | .3 | |
| Progressive | 53 | 33 | 1.45 (0.87-2.42) | .16 | |
| Untreated | Same | 170 | 70 | ||
| Improving | 67 | 35 | 1.05 (0.70-1.58) | .8 | |
| Progressive | 186 | 70 | 0.95 (0.68-1.34) | .8 | |
| Adjustment factors | |||||
| IPSS-R score at diagnosis | Very low | 81 | 27 | ||
| Low | 317 | 127 | 1.31 (0.86-2.00) | .2 | |
| Intermediate | 468 | 216 | 1.94 (1.27-2.96) | .002 | |
| High | 389 | 208 | 2.81 (1.81-4.35) | <.001 | |
| Very high | 222 | 145 | 4.12 (2.60-6.54) | <.001 | |
| Interval from diagnosis to HCT | 1477 | 723 | 1.05 (1.01-1.09) | .02 | |
| Age at HCT (dec) | 1477 | 723 | 1.12 (1.04-1.21) | .004 | |
| Conditioning | Standard | 493 | 223 | ||
| Reduced | 984 | 500 | 1.06 (0.9-1.26) | .5 | |
| Donor | Related | 533 | 245 | ||
| Unrelated | 944 | 478 | 1.19 (1.02-1.39) | .03 |
Multivariable Cox proportional hazards models for OS, with interactions between pretreatment and change in IPSS-R score. The total number of patients in each group and the number of events are reported in the N and D columns, respectively. The interval from diagnosis to HCT is in years, and age at HCT is in decades. Effect estimates are given with 95% CIs. Corresponding P values are calculated using the Wald test. All interaction effects between pretreatment and IPSS-R score change include both corresponding main effects.
dec, decades.