Table 2.

Calculations of the decision thresholds for thrombophilia testing

  • Low bleeding risk (5/1000)

Treatment threshold:

Pt=RV⋅(RRbleed−1)⋅Hnorx1−RRrx=1⋅(2.17−1)⋅0.0051−0.15=.0069=0.69%


Test vs no treatment threshold:

Ptt=RRt⋅Tp+(1−Tp)RRt⋅RV⋅(RRbleed−1)⋅Hnorx1−RRrx=1.65⋅0.38+(1−0.38)1.65⋅1⋅(2.17−1)⋅0.0051−.15=.0052=0.52%


Test vs treatment threshold:

Prx=(RRt⋅Tp+(1−Tp))⋅RV⋅(RRbleed−1)⋅Hnorx1−RRrx=(1.65⋅0.38+(1−0.38))⋅1⋅(2.17−1)⋅0.0051−0.15=0.0085=0.85%

  • High bleeding risk (15 per 1000)

  • Treatment threshold:


Pt=RV⋅(RRbleed−1)⋅Hnorx1−RRrx=1⋅(2.17−1)⋅0.0151−0.15=.0206=2.06%


Test vs no treatment threshold:

Ptt=RRt⋅Tp+(1−Tp)RRt⋅RV⋅(RRbleed−1)⋅Hnorx1−RRrx=1.65⋅0.38+(1−0.38)1.65⋅1⋅(2.17−1)⋅0.0151−.15=.01560417=1.56%


Test vs treatment threshold:

Prx=(RRt⋅Tp+(1−Tp))⋅RV⋅(RRbleed−1)⋅Hnorx1−RRrx=(1.65⋅0.38+(1−0.38))⋅1⋅(2.17−1)⋅0.0151−0.15=.0257=2.57%

 

  • Low bleeding risk (5/1000)

Treatment threshold:

Pt=RV⋅(RRbleed−1)⋅Hnorx1−RRrx=1⋅(2.17−1)⋅0.0051−0.15=.0069=0.69%


Test vs no treatment threshold:

Ptt=RRt⋅Tp+(1−Tp)RRt⋅RV⋅(RRbleed−1)⋅Hnorx1−RRrx=1.65⋅0.38+(1−0.38)1.65⋅1⋅(2.17−1)⋅0.0051−.15=.0052=0.52%


Test vs treatment threshold:

Prx=(RRt⋅Tp+(1−Tp))⋅RV⋅(RRbleed−1)⋅Hnorx1−RRrx=(1.65⋅0.38+(1−0.38))⋅1⋅(2.17−1)⋅0.0051−0.15=0.0085=0.85%

  • High bleeding risk (15 per 1000)

  • Treatment threshold:


Pt=RV⋅(RRbleed−1)⋅Hnorx1−RRrx=1⋅(2.17−1)⋅0.0151−0.15=.0206=2.06%


Test vs no treatment threshold:

Ptt=RRt⋅Tp+(1−Tp)RRt⋅RV⋅(RRbleed−1)⋅Hnorx1−RRrx=1.65⋅0.38+(1−0.38)1.65⋅1⋅(2.17−1)⋅0.0151−.15=.01560417=1.56%


Test vs treatment threshold:

Prx=(RRt⋅Tp+(1−Tp))⋅RV⋅(RRbleed−1)⋅Hnorx1−RRrx=(1.65⋅0.38+(1−0.38))⋅1⋅(2.17−1)⋅0.0151−0.15=.0257=2.57%

 
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