Multivariable analysis of transplant outcomes
| Covariate . | Group . | PGF . | aGVHD 2-4 . | cGVHD . | OS . | GRFS . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | ||
| Donor type | MUD | ||||||||||
| MMUD | 2.93 (1.52-5.6) | .001 | 1.96 (1.39-2.76) | <.001 | 1.3 (0.9-1.87) | .17 | 1.53 (1.12-2.09) | .007 | 1.41 (1.07-1.86) | .01 | |
| Haplo | 5.15 (2.5-10.58) | <.001 | 1.14 (0.72-1.8) | .6 | 0.96 (0.56-1.62) | .9 | 1.94 (1.34-2.8) | <.001 | 1.78 (1.29-2.46) | <.001 | |
| Donor age (decades) | 0.94 (0.72-1.22) | .5 | 1.1 (0.94-1.29) | .2 | 1.18 (1.01-1.38) | .03 | 1.12 (0.99-1.27) | .08 | 1.1 (0.99-1.23) | .08 | |
| Patient age (decades) | 0.92 (0.77-1.07) | .3 | 0.89 (0.81-0.97) | .01 | 1.18 (1.09-1.27) | <.001 | 1.26 (1.18-1.34) | <.001 | 1.15 (1.08-1.22) | <.001 | |
| Karnofsky score | 90-100 | ||||||||||
| <90 | 2.41 (1.38-4.15) | .002 | 0.84 (0.58-1.2) | .3 | 1.22 (0.88-1.69) | .2 | 1.47 (1.13-1.9) | .004 | 1.31 (1.04-1.66) | .02 | |
| TBI given | No | ||||||||||
| Yes | 0.78 (0.42-1.43) | .4 | 1.52 (1.1-2.12) | .01 | 1.07 (0.76-1.5) | .7 | 0.92 (0.69-1.22) | .19 | 0.98 (0.77-1.26) | .9 | |
| Stem cell source | Bone marrow | ||||||||||
| Peripheral blood | 0.79 (0.44-1.39) | .4 | 1.08 (0.78-1.49) | .6 | 1.07 (0.78-1.47) | .7 | 0.93 (0.71-1.04) | .6 | 0.93 (0.74-1.17) | .5 | |
| Interval from diagnosis to HCT (y) | 1.04 (0.96-1.11) | .3 | 1.01 (0.96-1.06) | .7 | 1.02 (0.99-1.06) | .2 | 1.01 (0.97-1.04) | .8 | 1.04 (1.01-1.07) | .006 | |
| Center effect | Variance | 0.4 | .03 | 0.35 | .08 | 0.39 | .003 | 0.16 | .06 | ||
| Covariate . | Group . | PGF . | aGVHD 2-4 . | cGVHD . | OS . | GRFS . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | ||
| Donor type | MUD | ||||||||||
| MMUD | 2.93 (1.52-5.6) | .001 | 1.96 (1.39-2.76) | <.001 | 1.3 (0.9-1.87) | .17 | 1.53 (1.12-2.09) | .007 | 1.41 (1.07-1.86) | .01 | |
| Haplo | 5.15 (2.5-10.58) | <.001 | 1.14 (0.72-1.8) | .6 | 0.96 (0.56-1.62) | .9 | 1.94 (1.34-2.8) | <.001 | 1.78 (1.29-2.46) | <.001 | |
| Donor age (decades) | 0.94 (0.72-1.22) | .5 | 1.1 (0.94-1.29) | .2 | 1.18 (1.01-1.38) | .03 | 1.12 (0.99-1.27) | .08 | 1.1 (0.99-1.23) | .08 | |
| Patient age (decades) | 0.92 (0.77-1.07) | .3 | 0.89 (0.81-0.97) | .01 | 1.18 (1.09-1.27) | <.001 | 1.26 (1.18-1.34) | <.001 | 1.15 (1.08-1.22) | <.001 | |
| Karnofsky score | 90-100 | ||||||||||
| <90 | 2.41 (1.38-4.15) | .002 | 0.84 (0.58-1.2) | .3 | 1.22 (0.88-1.69) | .2 | 1.47 (1.13-1.9) | .004 | 1.31 (1.04-1.66) | .02 | |
| TBI given | No | ||||||||||
| Yes | 0.78 (0.42-1.43) | .4 | 1.52 (1.1-2.12) | .01 | 1.07 (0.76-1.5) | .7 | 0.92 (0.69-1.22) | .19 | 0.98 (0.77-1.26) | .9 | |
| Stem cell source | Bone marrow | ||||||||||
| Peripheral blood | 0.79 (0.44-1.39) | .4 | 1.08 (0.78-1.49) | .6 | 1.07 (0.78-1.47) | .7 | 0.93 (0.71-1.04) | .6 | 0.93 (0.74-1.17) | .5 | |
| Interval from diagnosis to HCT (y) | 1.04 (0.96-1.11) | .3 | 1.01 (0.96-1.06) | .7 | 1.02 (0.99-1.06) | .2 | 1.01 (0.97-1.04) | .8 | 1.04 (1.01-1.07) | .006 | |
| Center effect | Variance | 0.4 | .03 | 0.35 | .08 | 0.39 | .003 | 0.16 | .06 | ||
Multivariable logistic regression model of PGF before day 42 and Cox cause–specific hazards models of aGVHD grade 2 to 4, cGVHD, OS, GVHD, and GRFS. Donor and patient age at transplant are in decades. Effect estimates are given with 95% CIs. Corresponding P values are calculated using the Wald test. No center effect was identified for PGF. Center variance was 0 and is thus, not reported here. P values considered statistically significant are shown in bold.